{"id":"W2073706224","doi":"10.1002/jgm.1420","title":"Improving adeno‐associated vector yield in high density insect cell cultures","year":2010,"lang":"en","type":"article","venue":"The Journal of Gene Medicine","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo; National Research Council Canada; Biotechnology Research Institute","funders":"","keywords":"Multiplicity of infection; Bioreactor; Titer; Yield (engineering); Recombinant DNA; Cell culture; Baculoviridae; Genetic enhancement; Viral vector; Biology; Virology; Transduction (biophysics); Adeno-associated virus; Vector (molecular biology); Virus; Gene; Materials science; Biochemistry; Genetics; Spodoptera","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006318226,0.0001279968,0.0002025497,0.00005652188,0.00009305961,0.000008541839,0.0002537589,0.0001346159,0.0000812604],"category_scores_gemma":[0.0006706465,0.00007236598,0.00007505391,0.000106007,0.00009668729,0.000004991451,0.00005773926,0.0003978822,0.000002029099],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001492078,"about_ca_system_score_gemma":0.00008011955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005486102,"about_ca_topic_score_gemma":0.0006121857,"domain_scores_codex":[0.9990731,0.0001038548,0.0003298576,0.0001089443,0.0002053147,0.0001789087],"domain_scores_gemma":[0.9991204,0.00004791856,0.0003364632,0.0002190206,0.0001721101,0.0001041503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001769268,0.00007644662,0.004037502,0.000008217068,0.00002667429,0.00001287878,0.0001687493,0.00005198597,0.9856986,0.000002589741,0.009405361,0.0003340886],"study_design_scores_gemma":[0.001525752,0.001283659,0.05522877,0.00005921996,0.00008663933,0.000129869,0.0001877706,0.00002189166,0.9402985,0.0001197004,0.0009192534,0.000138968],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996635,0.001415321,0.0001774789,0.0005316664,0.0009704986,0.0000803837,0.000003430011,0.000004076298,0.0001820979],"genre_scores_gemma":[0.9976133,0.0002797607,0.00006238253,0.0005740635,0.001230758,0.000001385124,0.000007118364,0.00001329247,0.0002179202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05119126,"threshold_uncertainty_score":0.2950999,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008346469992135232,"score_gpt":0.241265862577481,"score_spread":0.2329193925853458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}