{"id":"W2073707109","doi":"10.1016/j.bbrc.2005.08.229","title":"PTEN-induction in U251 glioma cells decreases the expression of insulin-like growth factor binding protein-2","year":2005,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"PTEN; Cancer research; Biology; PI3K/AKT/mTOR pathway; Insulin-like growth factor-binding protein; Glioma; LY294002; Cell growth; Tumor suppressor gene; Growth factor; Cell culture; Insulin-like growth factor; Signal transduction; Cell biology; Gene; Receptor; Biochemistry; Carcinogenesis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134596,0.0006531078,0.0004029096,0.0007395367,0.0003015311,0.0005250108,0.0003371086,0.0003262497,0.00239891],"category_scores_gemma":[0.0001504771,0.000273007,0.0005419086,0.000725521,0.0004291854,0.0003189401,0.0003072391,0.000974119,0.0008478137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006748774,"about_ca_system_score_gemma":0.0007683149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005219061,"about_ca_topic_score_gemma":0.004182961,"domain_scores_codex":[0.999675,0.00002762944,0.00002634861,0.00003984578,0.00009019879,0.0001409325],"domain_scores_gemma":[0.9998671,0.00001892234,0.00002734785,0.00001455649,0.00001071694,0.00006136149],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003952063,0.0001463427,0.0002725261,0.0000526898,0.00001623136,0.0001444127,0.00002887333,0.0001466249,0.9963511,0.0004019752,0.0004432525,0.00160082],"study_design_scores_gemma":[0.00003057,0.0003338991,0.003006384,0.000003051223,0.00002596009,0.0001658323,0.00004960283,0.0007958441,0.9928013,0.00008254105,0.002698763,0.000006325314],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894567,0.001769851,0.001542417,0.0004766789,0.0001666765,0.00003731772,0.001719679,0.000441683,0.004389036],"genre_scores_gemma":[0.9910437,0.001004754,0.0007796376,0.0001051994,0.00001969077,0.00004514977,0.002077361,0.00004034494,0.004884068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005219061,"threshold_uncertainty_score":0.01037741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05955833916378883,"score_gpt":0.3513400907867954,"score_spread":0.2917817516230066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}