{"id":"W2073720428","doi":"10.1210/en.2004-0777","title":"Activation of the Mammalian Target of Rapamycin Pathway Acutely Inhibits Insulin Signaling to Akt and Glucose Transport in 3T3-L1 and Human Adipocytes","year":2004,"lang":"en","type":"article","venue":"Endocrinology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval","funders":"Hospital for Sick Children","keywords":"P70-S6 Kinase 1; GLUT4; Internal medicine; Endocrinology; Insulin; PI3K/AKT/mTOR pathway; Insulin receptor; Protein kinase B; Glucose uptake; Glucose transporter; Phosphorylation; Insulin receptor substrate; IRS1; Biology; Chemistry; Signal transduction; Cell biology; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000787925,0.0001150012,0.0002119305,0.00006961252,0.00003290953,0.00000258504,0.0001020418,0.00008979053,0.00001090074],"category_scores_gemma":[0.00003044766,0.00009616943,0.00003785133,0.0000997216,0.0001174766,0.000005517153,0.00005132829,0.00008439548,2.505182e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008391937,"about_ca_system_score_gemma":0.0000533682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246669,"about_ca_topic_score_gemma":0.0001692792,"domain_scores_codex":[0.9991906,0.00005060739,0.0002521645,0.0002353317,0.00006706131,0.0002042842],"domain_scores_gemma":[0.9996518,0.000008754045,0.00009127332,0.0001679402,0.00003958141,0.00004063066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000769574,0.00006283155,0.01296263,0.00003729397,0.00002501899,0.000001593215,0.000364577,0.0001694433,0.9781888,0.0006217555,0.000007305407,0.007481853],"study_design_scores_gemma":[0.001113164,0.0002238678,0.03686497,0.00002907906,0.00001082093,0.000004645228,0.00008245687,4.459963e-7,0.9552079,0.0004088533,0.005960705,0.00009306476],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830533,0.01646824,0.0000607342,0.00007471293,0.00005252554,0.0001874198,0.00002462563,0.000003451165,0.00007494632],"genre_scores_gemma":[0.9981597,0.001216883,0.0002994357,0.0002019725,0.00005077244,0.00001888547,0.00002057151,0.00001132465,0.00002044393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02390234,"threshold_uncertainty_score":0.3921675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009089391411963178,"score_gpt":0.2315988992558692,"score_spread":0.2225095078439061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}