{"id":"W2073720428","doi":"10.1210/en.2004-0777","title":"Activation of the Mammalian Target of Rapamycin Pathway Acutely Inhibits Insulin Signaling to Akt and Glucose Transport in 3T3-L1 and Human Adipocytes","year":2004,"lang":"en","type":"article","venue":"Endocrinology","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":173,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Université Laval","funders":"Hospital for Sick Children","keywords":"P70-S6 Kinase 1; GLUT4; Internal medicine; Endocrinology; Insulin; PI3K/AKT/mTOR pathway; Insulin receptor; Protein kinase B; Glucose uptake; Glucose transporter; Phosphorylation; Insulin receptor substrate; IRS1; Biology; Chemistry; Signal transduction; Cell biology; Insulin resistance; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004011883,0.0006389917,0.0008814079,0.0004184253,0.0004127641,0.0006595213,0.0004149748,0.0004277554,0.00150785],"category_scores_gemma":[0.0002306199,0.0003634291,0.0009211918,0.0005046894,0.0005581968,0.000339773,0.0003714715,0.001588603,0.0006093613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008173906,"about_ca_system_score_gemma":0.0006928223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002911212,"about_ca_topic_score_gemma":0.004587046,"domain_scores_codex":[0.9994498,0.00009838495,0.0000752591,0.0001108588,0.0001078194,0.0001578193],"domain_scores_gemma":[0.9998492,0.00003476321,0.00003770306,0.0000229624,0.00001513471,0.00004022126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002398825,0.0003990459,0.0002589074,0.0001079919,0.00003524966,0.0002113355,0.00008468286,0.0001915107,0.9932414,0.0002215377,0.0003448664,0.002504592],"study_design_scores_gemma":[0.0002906495,0.00318502,0.007969213,0.0000182794,0.000082609,0.000570988,0.000124598,0.00185037,0.9805676,0.0001377029,0.005176717,0.00002625991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869887,0.006913591,0.002128507,0.0003947687,0.0001696958,0.00009303023,0.001266647,0.0002090467,0.001836088],"genre_scores_gemma":[0.9887583,0.003676645,0.002509192,0.0003081037,0.00004975616,0.0002423057,0.002411064,0.00007484329,0.001969887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002911212,"threshold_uncertainty_score":0.005930603,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009089391411963178,"score_gpt":0.2315988992558692,"score_spread":0.2225095078439061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}