{"id":"W2073739863","doi":"10.1016/j.antiviral.2014.06.020","title":"Analysis of the transcriptome and immune function of monocytes during IFNα-based therapy in chronic HCV revealed induction of TLR7 responsiveness","year":2014,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"Sociale en Geesteswetenschappen, NWO; Virgo Consortium; Bristol-Myers Squibb","keywords":"TLR7; Immunology; Immune system; Cytokine; Monocyte; In vivo; Interferon; Biology; Ex vivo; Transcriptome; Medicine; Toll-like receptor; Innate immune system; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001931988,0.000149348,0.0003844309,0.0001816324,0.0002801586,0.000448956,0.00007015071,0.0002610268,0.001557538],"category_scores_gemma":[0.0001842239,0.0001154403,0.0002711991,0.0001886583,0.0002200079,0.0001574247,0.0001851648,0.0004965428,0.0003788634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002376171,"about_ca_system_score_gemma":0.0002294284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004819965,"about_ca_topic_score_gemma":0.0009084117,"domain_scores_codex":[0.9998116,0.00003617211,0.00001071357,0.0000299795,0.00003273636,0.00007879766],"domain_scores_gemma":[0.9999045,0.0000199556,0.00001891879,0.00001114716,0.00001856543,0.00002685284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003424316,0.00006255578,0.007027142,0.00007329405,0.00001837168,0.0001417255,0.000161313,0.00009144812,0.9843136,0.00009619814,0.0001096423,0.004480298],"study_design_scores_gemma":[0.0001133546,0.002887296,0.5694171,0.00007825161,0.0002102186,0.0008955149,0.001968789,0.002421007,0.4173924,0.0005269335,0.004055163,0.00003401642],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977951,0.0005655872,0.0004776056,0.00004560364,0.00001918993,0.00001455944,0.000526741,0.000008012855,0.0005476854],"genre_scores_gemma":[0.9969153,0.0003886761,0.0003841342,0.00008090823,0.00001740175,0.00005284336,0.0006540003,0.000007517991,0.001499363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557538,"threshold_uncertainty_score":0.005210459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03344861648747564,"score_gpt":0.3130429138012755,"score_spread":0.2795942973137998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}