{"id":"W2073739863","doi":"10.1016/j.antiviral.2014.06.020","title":"Analysis of the transcriptome and immune function of monocytes during IFNα-based therapy in chronic HCV revealed induction of TLR7 responsiveness","year":2014,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Toronto","funders":"Sociale en Geesteswetenschappen, NWO; Virgo Consortium; Bristol-Myers Squibb","keywords":"TLR7; Immunology; Immune system; Cytokine; Monocyte; In vivo; Interferon; Biology; Ex vivo; Transcriptome; Medicine; Toll-like receptor; Innate immune system; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002219662,0.00008516019,0.0003534811,0.0009197047,0.00009782449,0.000004178475,0.000162601,0.0001566183,0.00002390082],"category_scores_gemma":[0.0002498759,0.00006314855,0.0001286157,0.001355673,0.0004190812,0.0001146843,0.00003823163,0.0002745341,0.000002193184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005256446,"about_ca_system_score_gemma":0.0001341475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005278078,"about_ca_topic_score_gemma":0.00007054143,"domain_scores_codex":[0.9972878,0.001806842,0.0004241579,0.0001654232,0.0001074952,0.0002082744],"domain_scores_gemma":[0.9988602,0.0004165827,0.0001694148,0.0003235489,0.0002261043,0.000004102653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003802548,0.00005717661,0.01873067,0.0000764846,0.0002431486,1.49837e-7,0.0003483305,0.00005716578,0.9644295,0.00016618,0.000001651366,0.01208701],"study_design_scores_gemma":[0.0008392671,0.0002930513,0.4671405,0.00005966596,0.00002930801,1.9792e-7,0.00008822426,0.0000830693,0.5313709,0.00003244129,0.00003353282,0.00002986308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973214,0.002129516,0.00004470506,0.0001037162,0.00006131353,0.0002526252,0.000003608116,0.000004797055,0.00007827466],"genre_scores_gemma":[0.9993324,0.0004098792,0.000002759904,0.000002448123,0.000006676924,0.00001327453,0.00001571413,0.000006916861,0.0002098785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4484099,"threshold_uncertainty_score":0.2575123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03344861648747564,"score_gpt":0.3130429138012755,"score_spread":0.2795942973137998,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}