{"id":"W2073756056","doi":"10.1016/j.ymgme.2010.06.010","title":"A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment","year":2010,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; McGill University","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Heart, Lung, and Blood Institute; Wellcome Trust","keywords":"Homocystinuria; Cystathionine beta synthase; Homocysteine; Steatosis; Methionine; Cysteine; Hyperhomocysteinemia; Transgene; Genetically modified mouse; Betaine; Endocrinology; Internal medicine; Chemistry; Medicine; Biology; Biochemistry; Gene; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001376203,0.0003278559,0.0006367398,0.0001787982,0.00009028721,0.00004319703,0.00009101444,0.0001817928,0.00004158931],"category_scores_gemma":[0.00002983574,0.0002066423,0.0001169757,0.0002471321,0.0001992271,0.00003959467,0.000069401,0.0001845398,0.000001630769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001507339,"about_ca_system_score_gemma":0.0001340784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003842567,"about_ca_topic_score_gemma":0.00009111411,"domain_scores_codex":[0.9983564,0.00004322313,0.0003304479,0.0004799695,0.0004264031,0.0003635538],"domain_scores_gemma":[0.9989651,0.00003694312,0.00009046438,0.0004114233,0.0002098232,0.0002862049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003202789,0.0004630382,0.0003280391,0.00009067743,0.0003072952,0.000005298357,0.001652602,0.00002934707,0.9884189,0.00003671186,0.00002230605,0.008325537],"study_design_scores_gemma":[0.003765271,0.000557918,0.002557583,0.000030311,0.0008897528,0.00001053766,0.000152632,0.02382551,0.9673482,0.00003990706,0.0005731413,0.0002492369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927342,0.003714317,0.001813275,0.0003210151,0.00003955565,0.0007479439,0.0005796322,0.00001936168,0.00003072747],"genre_scores_gemma":[0.9898337,0.002608943,0.006446163,0.0001961913,0.00002109599,0.000042666,0.00004208755,0.00005475065,0.0007543645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02379616,"threshold_uncertainty_score":0.8426628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02816986037765853,"score_gpt":0.2773869414836882,"score_spread":0.2492170811060297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}