{"id":"W2073757903","doi":"10.1111/j.1471-4159.2010.06683.x","title":"Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS","year":2010,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":183,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre hospitalier de l'Université Laval; Université Laval","funders":"Canadian Institutes of Health Research; ALS Society of Canada","keywords":"SOD1; Epitope; Monoclonal antibody; Immunogenicity; Antibody; Amyotrophic lateral sclerosis; Immunology; Monoclonal; Immunization; Chemistry; Medicine; Pharmacology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003282953,0.001030202,0.0007396569,0.0007592298,0.0002240796,0.0004329523,0.0005720979,0.0008118976,0.001288358],"category_scores_gemma":[0.0001827942,0.0003431146,0.0003430815,0.0002579051,0.0006450517,0.0005847023,0.0002369053,0.001803011,0.0004142231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004448784,"about_ca_system_score_gemma":0.000357285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006557779,"about_ca_topic_score_gemma":0.001248338,"domain_scores_codex":[0.9997222,0.00003611938,0.00003006815,0.00008366591,0.00005142875,0.00007653513],"domain_scores_gemma":[0.9996679,0.00004286776,0.0001040805,0.00003594238,0.00003117263,0.0001180412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000381533,0.0002003588,0.00009617503,0.000047283,0.00001126702,0.00005182656,0.00002500615,0.00007206764,0.9972927,0.00007626654,0.00005745799,0.001687983],"study_design_scores_gemma":[0.0001432104,0.003350163,0.001580948,0.00001752872,0.0000573899,0.0002274369,0.00002569785,0.001280531,0.9922994,0.0001138795,0.0008951447,0.000008792059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935645,0.001602245,0.003045761,0.0002140208,0.00008476811,0.00005107548,0.0003108078,0.0004108552,0.0007158201],"genre_scores_gemma":[0.9851561,0.002031342,0.005900268,0.0001452501,0.00008097143,0.0001104932,0.0007535123,0.0001078523,0.005714288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001288358,"threshold_uncertainty_score":0.004309952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0329477289517462,"score_gpt":0.3237163742144766,"score_spread":0.2907686452627304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}