{"id":"W2073760661","doi":"10.1038/ni.1933","title":"Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I","year":2010,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"RIG-I; Biology; Interferon; Inflammasome; Interferon type I; Virology; Caspase 8; Ubiquitin ligase; Ubiquitin; Virus; Innate immune system; Pattern recognition receptor; Interferon regulatory factors; Caspase 1; Caspase; Immune system; Apoptosis; Immunology; Programmed cell death; Inflammation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.0004937832,0.0003699977,0.000463162,0.0002055282,0.0005771275,0.00004151125,0.0005826948,0.00236123,0.005873831],"category_scores_gemma":[0.0005817325,0.000254655,0.0002448552,0.0001539982,0.0008655793,0.000168515,0.0001863959,0.005187645,0.00488718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006491634,"about_ca_system_score_gemma":0.0001070756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001179457,"about_ca_topic_score_gemma":0.001660516,"domain_scores_codex":[0.9976621,0.0007126648,0.0004392004,0.0004352891,0.00005301095,0.0006976823],"domain_scores_gemma":[0.9982215,0.000547901,0.0002286118,0.0008103203,0.0001687557,0.00002296737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001516095,0.000160558,0.0002948089,0.000003783827,0.0003883115,0.000005781104,0.0002064328,4.316062e-7,0.9704016,0.003458523,0.01124234,0.01232135],"study_design_scores_gemma":[0.001474703,0.0004511812,0.01324998,0.000008423173,0.00004440614,0.00043766,0.0000394314,0.000001832746,0.4981694,0.0001537519,0.4857478,0.0002214061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680113,0.008622869,0.0001045082,0.001760514,0.0161119,0.0005050919,0.00006053522,0.0002377942,0.004585456],"genre_scores_gemma":[0.9906268,0.0003161786,0.00002858541,0.001404956,0.000237604,0.00008920383,0.0001541747,0.00004103321,0.007101538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4745055,"threshold_uncertainty_score":0.9999906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004057799718977152,"score_gpt":0.235153049404603,"score_spread":0.2310952496856259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}