{"id":"W2073772755","doi":"10.1016/s0142-9612(02)00088-1","title":"Differential response to chemically altered polyethylene by activated mature human monocyte-derived macrophages","year":2002,"lang":"en","type":"article","venue":"Biomaterials","topic":"Orthopaedic implants and arthroplasty","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; University of Ottawa; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto","keywords":"High-density polyethylene; Monocyte; Polyethylene; Macrophage; Biophysics; Inflammation; Cytokine; Secretion; Materials science; Chemistry; Biochemistry; Immunology; Biology; Composite material; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003216119,0.0005802441,0.000421041,0.0002534503,0.0002490176,0.0005012595,0.0001998269,0.0005400945,0.002394673],"category_scores_gemma":[0.000345219,0.0002446575,0.0004421057,0.0002480193,0.0002732672,0.0002627794,0.0003122271,0.0005831496,0.0005675758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001462937,"about_ca_system_score_gemma":0.0001456709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002466276,"about_ca_topic_score_gemma":0.0004243608,"domain_scores_codex":[0.999508,0.0001456607,0.00003749949,0.00005215313,0.00007887869,0.0001777806],"domain_scores_gemma":[0.9997068,0.0001237021,0.0000311226,0.00003565978,0.00006604809,0.00003662608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001930455,0.00008349888,0.0009698115,0.00008484316,0.0000125989,0.0002946738,0.0001211062,0.00007933519,0.9946055,0.000119581,0.00004775856,0.001650764],"study_design_scores_gemma":[0.0002842981,0.004338358,0.03559074,0.00004237809,0.0001218263,0.001066938,0.0006774481,0.0009106045,0.953691,0.0002685058,0.002976121,0.00003164141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980484,0.0005031208,0.0004349893,0.00003577618,0.00004461305,0.00002400868,0.0001193742,0.000005906316,0.0007838676],"genre_scores_gemma":[0.995984,0.0007106878,0.0007506348,0.0001178949,0.00006946274,0.00006670731,0.0003330353,0.000009827344,0.001957889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002394673,"threshold_uncertainty_score":0.008010983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01962973717101101,"score_gpt":0.2716728061115571,"score_spread":0.2520430689405461,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}