{"id":"W2073776582","doi":"10.1016/j.it.2014.12.001","title":"Confusing signals: Recent progress in CTLA-4 biology","year":2015,"lang":"en","type":"review","venue":"Trends in Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":349,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Biotechnology and Biological Sciences Research Council; Diabetes UK","keywords":"CTLA-4; Cytotoxic T cell; CD28; Biology; Cell biology; Context (archaeology); Immunology; Function (biology); Immune system; Cytoplasm; Extracellular; T cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.001350567,0.001389144,0.005530438,0.003762325,0.0001411774,0.00003079782,0.001696968,0.004620007,0.003285672],"category_scores_gemma":[0.0001317372,0.00120274,0.0005473128,0.002252544,0.002110113,0.0001254795,0.0008583194,0.003568557,0.002785933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007906294,"about_ca_system_score_gemma":0.0008018013,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002411941,"about_ca_topic_score_gemma":0.0002613481,"domain_scores_codex":[0.9900019,0.003551397,0.002562184,0.001666913,0.0000657942,0.002151793],"domain_scores_gemma":[0.9967792,0.0005496534,0.001083185,0.001364847,0.0001697376,0.00005340112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001670198,0.0006974574,0.0001248674,0.0004703639,0.0007107473,0.0001530552,0.0002751674,4.707778e-7,0.002803606,0.0009200422,0.001829745,0.9918475],"study_design_scores_gemma":[0.003194775,0.0006091539,0.00002301462,0.002032686,0.0003010176,0.0007578445,0.00009137001,5.299053e-7,0.0002837235,0.0003950715,0.9912162,0.001094588],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004278017,0.9876643,0.000003420704,0.0001954515,0.004577327,0.0007123266,0.000113809,0.0002125469,0.006092961],"genre_scores_gemma":[0.001108063,0.9907986,0.00007440649,0.00006558131,0.00008987263,0.0005234529,0.002869665,0.000152006,0.004318385],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9907529,"threshold_uncertainty_score":0.9998859,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07867480032650645,"score_gpt":0.3570312429289401,"score_spread":0.2783564426024336,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}