{"id":"W2073782067","doi":"10.12688/f1000research.5512.2","title":"Diversity of two-component systems: insights into the signal transduction mechanism by the Staphylococcus aureus two-component system GraSR","year":2014,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation","keywords":"Response regulator; Histidine kinase; Autophosphorylation; Biology; ATP-binding cassette transporter; Signal transduction; Two-component regulatory system; Bacillus subtilis; Cell biology; Twin-arginine translocation pathway; Signal transducing adaptor protein; Protein kinase domain; Histidine; Biochemistry; Protein kinase A; Kinase; Genetics; Transporter; Membrane transport protein; Gene; Bacteria; Bacterial protein; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003119218,0.0005579878,0.0005722217,0.0004931744,0.0002119357,0.0007699772,0.0003335655,0.0008562722,0.001222676],"category_scores_gemma":[0.000326935,0.0002297922,0.00047016,0.0002568759,0.0004385808,0.001222005,0.000540028,0.0008421415,0.0006000532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007536727,"about_ca_system_score_gemma":0.0003674932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006151519,"about_ca_topic_score_gemma":0.000507505,"domain_scores_codex":[0.9997467,0.0000468385,0.0000180417,0.00005591739,0.00008806751,0.00004443801],"domain_scores_gemma":[0.9998899,0.00002986148,0.00002087335,0.0000143989,0.00002160756,0.000023402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007919515,0.00003241124,0.001031995,0.000282014,0.00001439958,0.0003716033,0.0001234845,0.001490254,0.9773425,0.004973437,0.0002180925,0.01404058],"study_design_scores_gemma":[0.0001562982,0.001295276,0.04168903,0.0002956135,0.0001470781,0.006034216,0.001258262,0.09478527,0.7550847,0.02759348,0.07146036,0.0002004936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8793747,0.03460154,0.06707241,0.002739905,0.0001900538,0.0001073539,0.0003395204,0.0007497934,0.01482473],"genre_scores_gemma":[0.9678076,0.00738343,0.02187256,0.0004263576,0.00003508711,0.00005291406,0.0003099327,0.00004398149,0.002068096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001222676,"threshold_uncertainty_score":0.005468309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02712232541767215,"score_gpt":0.2932600764641405,"score_spread":0.2661377510464684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}