{"id":"W2073794835","doi":"10.1074/jbc.m115.638577","title":"Mdm2 Promotes Myogenesis through the Ubiquitination and Degradation of CCAAT/Enhancer-binding Protein β","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Myogenesis; MyoD; MyoD Protein; Myocyte; Ubiquitin ligase; Myogenin; Cell biology; Biology; Ubiquitin; Ccaat-enhancer-binding proteins; Protein degradation; Gene knockdown; Cellular differentiation; Molecular biology; Small hairpin RNA; Nuclear protein; Transcription factor; Biochemistry; Cell culture; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003026518,0.0000903601,0.0001432438,0.000007641314,0.00004393643,0.000007492731,0.0001420723,0.0001669326,0.00001316408],"category_scores_gemma":[0.0004511602,0.00005368442,0.00006546667,0.00005345572,0.0001768151,0.000007611518,0.00005953641,0.00009650675,4.244541e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008990663,"about_ca_system_score_gemma":0.00006001088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002496223,"about_ca_topic_score_gemma":5.016994e-7,"domain_scores_codex":[0.9993609,0.00006099722,0.0002589959,0.0001224372,0.0000929559,0.0001037426],"domain_scores_gemma":[0.9993328,0.00002248003,0.0003274126,0.0001002096,0.0001710509,0.00004598732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001958437,0.0000562107,0.0004611483,0.00002399356,0.00002886655,5.784115e-7,0.0000318021,0.000006585046,0.9978021,0.00002649227,0.0001553248,0.00121108],"study_design_scores_gemma":[0.0003807087,0.0003796284,0.0003848676,0.00002111281,0.00001226941,0.00002623991,0.0003148606,0.000005522315,0.9966531,0.001088302,0.0006636829,0.00006970571],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997703,0.001022119,0.0003386739,0.0003139271,0.00002888524,0.0000806457,0.000004519482,0.000002506216,0.0005057925],"genre_scores_gemma":[0.9989418,0.0001419297,0.0006111528,0.00001969422,0.000132665,0.000005697546,0.000021174,0.00000416135,0.0001217132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001238882,"threshold_uncertainty_score":0.2189187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03452320986075665,"score_gpt":0.2760546751420471,"score_spread":0.2415314652812905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}