{"id":"W2073794835","doi":"10.1074/jbc.m115.638577","title":"Mdm2 Promotes Myogenesis through the Ubiquitination and Degradation of CCAAT/Enhancer-binding Protein β","year":2015,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Myogenesis; MyoD; MyoD Protein; Myocyte; Ubiquitin ligase; Myogenin; Cell biology; Biology; Ubiquitin; Ccaat-enhancer-binding proteins; Protein degradation; Gene knockdown; Cellular differentiation; Molecular biology; Small hairpin RNA; Nuclear protein; Transcription factor; Biochemistry; Cell culture; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196493,0.0002952002,0.0002118928,0.0001957702,0.0002483688,0.0002578227,0.0001017062,0.0001719935,0.001776309],"category_scores_gemma":[0.000102906,0.0001269728,0.0002152493,0.0001125274,0.0001651867,0.0001587765,0.0003189782,0.000300451,0.0004469195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001720284,"about_ca_system_score_gemma":0.0001348356,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002535895,"about_ca_topic_score_gemma":0.0004402259,"domain_scores_codex":[0.9998823,0.0000165963,0.00001124368,0.00002662255,0.00002754277,0.00003566604],"domain_scores_gemma":[0.9999394,0.000008542185,0.00001767877,0.000007250737,0.000006977383,0.00002008238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000124158,0.00002227318,0.0007001794,0.00004842964,0.00000629746,0.0001326551,0.00001121492,0.00005107512,0.9974461,0.0001270486,0.00009145356,0.001239197],"study_design_scores_gemma":[0.00001705937,0.0001455535,0.01946835,0.00001009876,0.0000132309,0.0005331258,0.00003397147,0.0007969294,0.9721587,0.00007592073,0.006741592,0.000005420853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903278,0.003447312,0.002689391,0.0001627578,0.00004930506,0.00001791302,0.0003645827,0.0001275925,0.002813329],"genre_scores_gemma":[0.9947751,0.0009261217,0.0007718715,0.00003232383,0.00001680608,0.00001939411,0.0002727819,0.00001189588,0.003173766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001776309,"threshold_uncertainty_score":0.005942345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03452320986075665,"score_gpt":0.2760546751420471,"score_spread":0.2415314652812905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}