{"id":"W2073824449","doi":"10.1126/science.1211037","title":"Active Starvation Responses Mediate Antibiotic Tolerance in Biofilms and Nutrient-Limited Bacteria","year":2011,"lang":"en","type":"article","venue":"Science","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":994,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique; McGill University","funders":"National Heart, Lung, and Blood Institute; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Multidrug tolerance; Antibiotics; Bacteria; Starvation; Biofilm; Pseudomonas aeruginosa; Microbiology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002471407,0.0003285132,0.0002562018,0.0001718314,0.000247223,0.0002756397,0.0001637733,0.0003134356,0.0005943145],"category_scores_gemma":[0.0002165819,0.0001475305,0.0001730177,0.00008595319,0.000312192,0.0002919058,0.0005029663,0.00045275,0.0001838363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001773586,"about_ca_system_score_gemma":0.0002068881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003050457,"about_ca_topic_score_gemma":0.0005125983,"domain_scores_codex":[0.9998299,0.00003891141,0.00001321683,0.00002157258,0.00006717393,0.00002911594],"domain_scores_gemma":[0.9998304,0.00002535681,0.00005760551,0.00001487791,0.00003117611,0.00004062694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000227694,0.000005235613,0.0001489382,0.00001908209,9.415394e-7,0.00001547238,0.0000106055,0.000009281314,0.9991801,0.000066811,0.000008579263,0.0005122106],"study_design_scores_gemma":[0.00001519826,0.0003678334,0.02119392,0.00001341559,0.000009859478,0.0004201286,0.00006818499,0.0006428737,0.9752513,0.0005721901,0.001431922,0.00001324177],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901969,0.00446776,0.004001627,0.0002381876,0.00002249735,0.00001825816,0.00005538626,0.00003230359,0.0009668646],"genre_scores_gemma":[0.9968923,0.0009259308,0.001362202,0.00006274441,0.0000109369,0.00001351024,0.00005153202,0.000005115755,0.0006758429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005943145,"threshold_uncertainty_score":0.001988173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01971889755107726,"score_gpt":0.2439724537620176,"score_spread":0.2242535562109403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}