{"id":"W2073929542","doi":"10.1016/j.ymgme.2008.05.001","title":"Heparin cofactor II–thrombin complex: A biomarker of MPS disease","year":2008,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Université de Montréal; University of Alberta; University of Calgary; McGill University; University of British Columbia","funders":"National MPS Society; Child and Family Research Institute","keywords":"Enzyme replacement therapy; Heparin cofactor II; Biomarker; Medicine; Hurler syndrome; Disease; Heparin; Mucopolysaccharidosis; Thrombin; Mucopolysaccharidosis I; Glycosaminoglycan; Hunter syndrome; Internal medicine; Immunology; Platelet; Gastroenterology; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008568563,0.0001644715,0.0003587897,0.0001268765,0.0001076508,0.000008277686,0.0001025055,0.00006618179,0.0001739133],"category_scores_gemma":[0.0000865842,0.0001467388,0.0001251749,0.0002060283,0.0002821468,0.00002242267,0.0001781044,0.0001017331,0.000007194897],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001085978,"about_ca_system_score_gemma":0.0001332959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001112687,"about_ca_topic_score_gemma":0.000003613395,"domain_scores_codex":[0.998677,0.00005835027,0.0002385444,0.0002832981,0.0004562542,0.0002865125],"domain_scores_gemma":[0.9989942,0.00001219657,0.00005291012,0.0003852581,0.0001558558,0.0003995315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002611373,0.0005681952,0.01741296,0.0001231395,0.0002347187,0.0004693313,0.0003520554,0.000007211293,0.9719798,0.001074306,0.001553987,0.005963191],"study_design_scores_gemma":[0.002545282,0.0001195221,0.907032,0.00001935219,0.0001833926,0.00007829216,0.00002300588,0.0007163081,0.03583311,0.000381472,0.05286816,0.0002000628],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9763938,0.02134285,0.0004962725,0.0005161162,0.00005336853,0.0003925172,0.00003637595,0.00001792768,0.0007507662],"genre_scores_gemma":[0.9953911,0.002427783,0.001379808,0.0003875542,0.00002484408,0.00001553526,0.00004340281,0.00003277635,0.0002972486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9361467,"threshold_uncertainty_score":0.5983834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04403328401767525,"score_gpt":0.2992889262848228,"score_spread":0.2552556422671476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}