{"id":"W2073929542","doi":"10.1016/j.ymgme.2008.05.001","title":"Heparin cofactor II–thrombin complex: A biomarker of MPS disease","year":2008,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Université de Montréal; University of Alberta; University of Calgary; McGill University; University of British Columbia","funders":"National MPS Society; Child and Family Research Institute","keywords":"Enzyme replacement therapy; Heparin cofactor II; Biomarker; Medicine; Hurler syndrome; Disease; Heparin; Mucopolysaccharidosis; Thrombin; Mucopolysaccharidosis I; Glycosaminoglycan; Hunter syndrome; Internal medicine; Immunology; Platelet; Gastroenterology; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007150045,0.00061907,0.0005492821,0.002452162,0.0004024112,0.001106565,0.0004644554,0.001017252,0.001708385],"category_scores_gemma":[0.002570058,0.0003217708,0.0002046624,0.0008619081,0.0003692915,0.0004319583,0.0003153942,0.0007081861,0.0003406759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003759439,"about_ca_system_score_gemma":0.0004024877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001665367,"about_ca_topic_score_gemma":0.0009055651,"domain_scores_codex":[0.9996202,0.00008888151,0.00005684972,0.00005471894,0.000141442,0.00003791894],"domain_scores_gemma":[0.9991658,0.0002993467,0.0001574561,0.00003801041,0.0001361263,0.0002032624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003391179,0.0002560182,0.6546661,0.0003768699,0.0005204531,0.01364613,0.0004628589,0.0004855451,0.2781637,0.001069769,0.002352246,0.04460917],"study_design_scores_gemma":[0.0001842684,0.00180358,0.7424238,0.000138902,0.0008833357,0.08928286,0.0005974016,0.007238191,0.1473969,0.001821285,0.008169427,0.00006006473],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870122,0.006475577,0.002266895,0.0004559638,0.00007380938,0.00004316256,0.0003496239,0.00008045361,0.003242224],"genre_scores_gemma":[0.9975517,0.0004670218,0.001270921,0.00005516568,0.00004844461,0.000009325648,0.0001216676,0.000007124907,0.0004685395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002452162,"threshold_uncertainty_score":0.005715132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04403328401767525,"score_gpt":0.2992889262848228,"score_spread":0.2552556422671476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}