{"id":"W2073950729","doi":"10.1371/journal.pone.0057062","title":"Functional Rescue of a Kidney Anion Exchanger 1 Trafficking Mutant in Renal Epithelial Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Mutant; Distal renal tubular acidosis; Endoplasmic reticulum; Intercalated Cell; Golgi apparatus; Biology; Cell biology; HEK 293 cells; Kidney; Molecular biology; Chemistry; Biochemistry; Gene; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002728579,0.0004445096,0.0005318132,0.0002067867,0.0002814788,0.0003640245,0.0004808522,0.0006276408,0.00129794],"category_scores_gemma":[0.0001801053,0.0001904774,0.0004811717,0.0001511728,0.00028049,0.0002252032,0.0003503718,0.0007621686,0.0006602757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003077428,"about_ca_system_score_gemma":0.0003809284,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115298,"about_ca_topic_score_gemma":0.0009489373,"domain_scores_codex":[0.9996837,0.00006315938,0.00005282511,0.00005591594,0.00009415208,0.00005023341],"domain_scores_gemma":[0.9998109,0.00003694438,0.00004822069,0.00004117931,0.0000235606,0.00003913799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003375642,0.00001351482,0.00003624061,0.00002093506,0.0000035359,0.000062974,0.00001252247,0.00005901428,0.9993832,0.00007565215,0.00002021804,0.0002784642],"study_design_scores_gemma":[0.00001743141,0.0001444193,0.00095297,0.000004537698,0.00001181106,0.0003125136,0.00003850527,0.0007250155,0.9958405,0.00002586828,0.00192132,0.000005146885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928902,0.0006701493,0.003840689,0.0002577892,0.00008031226,0.00005155911,0.0008734866,0.0001358729,0.00119985],"genre_scores_gemma":[0.990307,0.0007148476,0.004108751,0.00008789954,0.00001011247,0.00006422085,0.001030391,0.00007587227,0.003600849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00129794,"threshold_uncertainty_score":0.004342079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109728496083828,"score_gpt":0.194569015070344,"score_spread":0.1734717301095057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}