{"id":"W2073950729","doi":"10.1371/journal.pone.0057062","title":"Functional Rescue of a Kidney Anion Exchanger 1 Trafficking Mutant in Renal Epithelial Cells","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates","keywords":"Mutant; Distal renal tubular acidosis; Endoplasmic reticulum; Intercalated Cell; Golgi apparatus; Biology; Cell biology; HEK 293 cells; Kidney; Molecular biology; Chemistry; Biochemistry; Gene; Genetics; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007822005,0.00007571239,0.0001043204,0.00004975668,0.00001933797,0.000005050534,0.00004853755,0.0001033667,0.0002285553],"category_scores_gemma":[0.0000176746,0.00007259565,0.00004202094,0.00006447994,0.00002750516,0.000004883767,0.00001150287,0.00005046263,0.00001536617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008124302,"about_ca_system_score_gemma":0.00004140678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003442419,"about_ca_topic_score_gemma":0.0000245505,"domain_scores_codex":[0.9993692,0.00002011135,0.0001721172,0.0001598862,0.0001519901,0.0001266747],"domain_scores_gemma":[0.9997058,0.000003016421,0.00004278129,0.0001085456,0.00007564249,0.00006421904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007413269,0.0003174245,0.0004752369,0.00003859382,0.00003550452,7.495124e-7,0.00007614848,0.00009397017,0.998323,0.00001301659,0.0002880471,0.0002642233],"study_design_scores_gemma":[0.0004830059,0.0001165255,0.008470195,0.00006294078,0.00001785703,6.768617e-7,0.00002373303,0.0004598396,0.9900153,0.00004098217,0.0002215956,0.00008729117],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990126,0.00005574048,0.0003464771,0.0002011358,0.00005482241,0.0001663233,0.00001948447,0.000006303752,0.0001371244],"genre_scores_gemma":[0.9986368,0.00004603917,0.0002919863,0.00009422551,0.0002657994,0.00002511987,0.000214869,0.00001143484,0.0004137219],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008307596,"threshold_uncertainty_score":0.2960365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109728496083828,"score_gpt":0.194569015070344,"score_spread":0.1734717301095057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}