{"id":"W2073968654","doi":"10.1074/jbc.m803603200","title":"ADP-ribosylation Factor 1 Controls the Activation of the Phosphatidylinositol 3-Kinase Pathway to Regulate Epidermal Growth Factor-dependent Growth and Migration of Breast Cancer Cells","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Université de Montréal","funders":"","keywords":"Cell biology; Epidermal growth factor; Cell growth; Biology; PI3K/AKT/mTOR pathway; Cancer research; Cell migration; Growth factor; Epidermal growth factor receptor; Signal transduction; ADP ribosylation factor; Kinase; GTPase; Cancer cell; Cancer; Cell; Golgi apparatus; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180367,0.0001328752,0.0002170398,0.0000137468,0.00007388526,0.00000664008,0.0001641483,0.0001915532,0.00002952905],"category_scores_gemma":[0.00006587012,0.00007196127,0.0001578911,0.00007186844,0.0001096725,0.00001123887,0.0000325232,0.0001365273,1.013318e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001705747,"about_ca_system_score_gemma":0.00006618247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003626998,"about_ca_topic_score_gemma":0.000003869635,"domain_scores_codex":[0.9990358,0.00005947076,0.0004382099,0.0001484166,0.0002008556,0.0001172633],"domain_scores_gemma":[0.9989819,0.00003611779,0.0005190345,0.0001279199,0.0002684436,0.00006659073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000350311,0.0000553035,0.05885115,0.00003109675,0.00004064605,0.000001334488,0.00008819712,0.00004570889,0.9403127,0.000004388352,0.00001134159,0.0002078149],"study_design_scores_gemma":[0.0003597869,0.00009057865,0.2475006,0.00002915568,0.00001334508,0.00002741642,0.0000284169,0.00001512409,0.7517639,0.00001602797,0.00009001469,0.00006560396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997644,0.0003132279,0.0011606,0.0005386362,0.00006060973,0.0001495454,0.0001144935,0.000002051963,0.00001683547],"genre_scores_gemma":[0.9990947,0.0005237169,0.0000384626,0.00007395051,0.0001790416,0.000003628521,0.00005244104,0.000006253752,0.00002781541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1886494,"threshold_uncertainty_score":0.2934495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01349324515399628,"score_gpt":0.2155889514923862,"score_spread":0.2020957063383899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}