{"id":"W2073971889","doi":"10.1016/j.ejmech.2011.05.058","title":"Synthesis and biological evaluation of the glycoside (25R)-3β,16β-diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside: A selective anticancer agent in cervicouterine cell lines","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; HeLa; Diosgenin; Cytotoxic T cell; Apoptosis; Glycoside; Cytotoxicity; Cell culture; Cancer cell; Programmed cell death; Biological activity; Cell growth; Cell cycle; Stereochemistry; Biochemistry; Cancer; Cell; Pharmacology; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001235084,0.0001900333,0.0003033997,0.0000226787,0.00004572705,0.000006934475,0.0002881517,0.0000774835,0.00005510446],"category_scores_gemma":[0.0005659579,0.0001191426,0.0001240343,0.0001068754,0.0002873883,0.000007338338,0.0001856988,0.0002705773,6.820752e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004531589,"about_ca_system_score_gemma":0.000086974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001818582,"about_ca_topic_score_gemma":0.000004132974,"domain_scores_codex":[0.9984295,0.0003162198,0.0004692596,0.0002274283,0.0003561952,0.0002014137],"domain_scores_gemma":[0.9990146,0.00006196488,0.0003895106,0.0001800895,0.0002596567,0.00009424268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000377686,0.0001556536,0.008670713,0.00007393835,0.00008068988,0.00001878226,0.0002576876,0.00000485347,0.9863899,4.646894e-7,0.0003176744,0.003651917],"study_design_scores_gemma":[0.0009683785,0.0002699697,0.08316075,0.0002072597,0.000118494,0.000100292,0.000533651,0.00001703327,0.9139135,0.00003066614,0.0005489562,0.0001309773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931548,0.003459791,0.00005151249,0.0002041919,0.00009797773,0.000119823,0.00000924666,0.000003350101,0.002899267],"genre_scores_gemma":[0.9981859,0.001055043,0.0001654585,0.0001219551,0.0004168377,0.000007086594,0.000001639315,0.00001825465,0.00002779872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07449004,"threshold_uncertainty_score":0.4858496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03086573557222873,"score_gpt":0.2531132028002294,"score_spread":0.2222474672280007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}