{"id":"W2073971889","doi":"10.1016/j.ejmech.2011.05.058","title":"Synthesis and biological evaluation of the glycoside (25R)-3β,16β-diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside: A selective anticancer agent in cervicouterine cell lines","year":2011,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; HeLa; Diosgenin; Cytotoxic T cell; Apoptosis; Glycoside; Cytotoxicity; Cell culture; Cancer cell; Programmed cell death; Biological activity; Cell growth; Cell cycle; Stereochemistry; Biochemistry; Cancer; Cell; Pharmacology; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371569,0.0003969209,0.0002746214,0.0003006728,0.0002231696,0.0001899314,0.0002261819,0.0001982543,0.001188335],"category_scores_gemma":[0.00007652865,0.0001159897,0.0002345346,0.0003388039,0.0001790831,0.000140221,0.000154313,0.0002353525,0.0004343458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037824,"about_ca_system_score_gemma":0.0003938318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001313651,"about_ca_topic_score_gemma":0.001698992,"domain_scores_codex":[0.9999541,0.000008030148,0.000005067159,0.00001013573,0.00000853889,0.00001407755],"domain_scores_gemma":[0.9999372,0.000005341749,0.00001003469,0.000009960799,0.00001202795,0.00002550769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002129535,0.0000798266,0.0001557746,0.00005863555,0.000007286126,0.0001537476,0.00003052844,0.0002465165,0.9944032,0.00013978,0.00004651167,0.004465295],"study_design_scores_gemma":[0.00004188639,0.001087307,0.001718805,0.000005421062,0.00004173057,0.0002064436,0.00002536316,0.0001495839,0.9923028,0.00002855153,0.004385145,0.000006996608],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868794,0.003948969,0.003158652,0.00008258496,0.00003657793,0.0002240785,0.001313161,0.00006857813,0.004288089],"genre_scores_gemma":[0.9865537,0.003289707,0.004020799,0.0000453942,0.00001751126,0.00007284685,0.001390305,0.00001956039,0.0045902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001313651,"threshold_uncertainty_score":0.003975391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03086573557222873,"score_gpt":0.2531132028002294,"score_spread":0.2222474672280007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}