{"id":"W2074004596","doi":"10.1038/srep08554","title":"Families of Nuclear Receptors in Vertebrate Models: Characteristic and Comparative Toxicological Perspective","year":2015,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Higher Education Discipline Innovation Project; National Natural Science Foundation of China; State Key Laboratory in Marine Pollution; City University of Hong Kong","keywords":"Phylogenetic tree; Biology; Vertebrate; Zebrafish; Nuclear receptor; Phylogenetics; Evolutionary biology; Gene; Conserved sequence; Pregnane X receptor; Genetics; Zoology; Computational biology; Transcription factor; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004035373,0.000360175,0.0003685988,0.001523321,0.0003008793,0.0004962144,0.0003748165,0.0003343184,0.00173491],"category_scores_gemma":[0.0001731242,0.0001410581,0.0005312159,0.00120869,0.000449556,0.0004378621,0.0004192435,0.0005532593,0.0005260026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004035517,"about_ca_system_score_gemma":0.0003128561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002264068,"about_ca_topic_score_gemma":0.002699314,"domain_scores_codex":[0.9997783,0.00005586169,0.00002052847,0.000072856,0.00004572008,0.00002674498],"domain_scores_gemma":[0.9998986,0.00001107394,0.00004198353,0.00001050519,0.00002009004,0.00001781178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001574968,0.0001490268,0.04651341,0.003213839,0.000411564,0.002103021,0.000808334,0.00150616,0.6333694,0.02740562,0.008758879,0.2741858],"study_design_scores_gemma":[0.0001004824,0.001862663,0.3422365,0.0008046201,0.0009448095,0.02088027,0.001220545,0.004471478,0.06177702,0.01047937,0.5550964,0.0001259336],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4733654,0.4024568,0.06841175,0.003082783,0.0005323761,0.0002382577,0.01305235,0.001328242,0.03753219],"genre_scores_gemma":[0.7709795,0.1526675,0.04757936,0.0008652617,0.0002930182,0.0004569311,0.009926752,0.0001275756,0.01710405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002264068,"threshold_uncertainty_score":0.005803883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03614352431562752,"score_gpt":0.2688067602189234,"score_spread":0.2326632359032959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}