{"id":"W2074036828","doi":"10.1111/j.1399-0039.2009.01361.x","title":"A bioinformatics approach to ascertaining the rarity of HLA alleles","year":2009,"lang":"en","type":"article","venue":"Tissue Antigens","topic":"vaccines and immunoinformatics approaches","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Blood Services","funders":"","keywords":"Human leukocyte antigen; Allele; Major histocompatibility complex; Histocompatibility; Biology; Genetics; Histocompatibility Testing; Mechanism (biology); Computational biology; Genealogy; Gene; Antigen; History; Philosophy; Epistemology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005993227,0.001158557,0.001759313,0.006197487,0.001832468,0.002906821,0.001679097,0.001196993,0.00364546],"category_scores_gemma":[0.01303632,0.0006327272,0.002479839,0.005333455,0.0005509106,0.001258152,0.001425796,0.001668638,0.00327186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009378855,"about_ca_system_score_gemma":0.003100661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003090675,"about_ca_topic_score_gemma":0.005703132,"domain_scores_codex":[0.9959721,0.001453251,0.0004634477,0.001187195,0.0007444628,0.0001795794],"domain_scores_gemma":[0.9938663,0.003915281,0.0003368197,0.0005858181,0.0009631755,0.0003326075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002790094,0.001933771,0.04876881,0.00230062,0.001569619,0.00205756,0.00150475,0.04723454,0.06641833,0.02634905,0.04999941,0.7490734],"study_design_scores_gemma":[0.000586707,0.001338942,0.02880276,0.0002713432,0.0009815594,0.002762285,0.0009622407,0.7219894,0.03966992,0.107842,0.09451646,0.0002763559],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.03129945,0.0007344679,0.9304228,0.001152245,0.0001821352,0.0007640962,0.01692554,0.01571415,0.002805132],"genre_scores_gemma":[0.07210064,0.0003529816,0.9038395,0.0004134815,0.0001052124,0.0005940358,0.02061064,0.0004600726,0.001523468],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.006197487,"threshold_uncertainty_score":0.0316956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01830596481004863,"score_gpt":0.2594406299508473,"score_spread":0.2411346651407987,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}