{"id":"W2074063971","doi":"10.1038/nchembio.1757","title":"Untwisting the antibiotic'ome","year":2015,"lang":"en","type":"letter","venue":"Nature Chemical Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"DNA gyrase; Natural product; Antibiotics; Computational biology; Protein subunit; Chemistry; Bacteria; Biology; Microbiology; Stereochemistry; Combinatorial chemistry; Genetics; Biochemistry; Escherichia coli; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003109839,0.0006236415,0.0009570207,0.0003786433,0.003172843,0.003038735,0.001489932,0.03961085,0.003731144],"category_scores_gemma":[0.01973546,0.0006024152,0.0007532071,0.0002743744,0.0059929,0.004079064,0.002595345,0.03918912,0.002532564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003494042,"about_ca_system_score_gemma":0.002468378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002839386,"about_ca_topic_score_gemma":0.005138595,"domain_scores_codex":[0.9971801,0.0007809363,0.0002116182,0.0003497116,0.001035185,0.0004424674],"domain_scores_gemma":[0.9951932,0.003204302,0.0002903828,0.0002592911,0.0003525405,0.0007001267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001177802,0.0000547878,0.0003497344,0.00008993476,0.00003113251,0.002205024,0.0002506471,0.0001104643,0.0005938956,0.02589815,0.948835,0.02146355],"study_design_scores_gemma":[0.0001554289,0.0001477955,0.0005173404,0.0001637389,0.00002784999,0.001604578,0.0003135928,0.0004803659,0.0008894596,0.04855362,0.9470792,0.00006698448],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0006281808,0.004037707,0.0002345495,0.9702382,0.02101322,0.000006704437,0.00001922949,0.0000329707,0.003789219],"genre_scores_gemma":[0.0172789,0.0021145,0.0002793642,0.9499897,0.02262552,0.00002287622,0.00001235351,0.00002633795,0.007650438],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03961085,"threshold_uncertainty_score":0.02535117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861927681390386,"score_gpt":0.2792191017810693,"score_spread":0.2605998249671654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}