{"id":"W2074088645","doi":"10.1159/000339364","title":"Combining Structural Brain Changes Improves the Prediction of Alzheimer’s Disease and Mild Cognitive Impairment","year":2012,"lang":"en","type":"article","venue":"Dementia and Geriatric Cognitive Disorders","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; National Research Council Canada; National Research Council Institute for Biodiagnostics","funders":"National Institute on Aging; National Key Research and Development Program of China; University of California, San Diego; National Institute of Biomedical Imaging and Bioengineering; National Research Council Canada; University of California, Los Angeles; National Institutes of Health; National Natural Science Foundation of China; Eisai; Genentech; Tianjin Medical University; Northern California Institute for Research and Education; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; Alzheimer's Association; Nova Scotia Health Research Foundation; Medpace; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Pfizer; Elan; Novartis; Synarc; Dana Foundation; Foundation for the National Institutes of Health","keywords":"Alzheimer's disease; Dementia; Psychology; Cognitive impairment; Degenerative disease; Cognition; Disease; Neuroscience; Cognitive disorder; Central nervous system disease; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004453052,0.000271043,0.0002986707,0.0002097171,0.0003152894,0.00004398635,0.00005128602,0.00006110406,0.0001345044],"category_scores_gemma":[0.0001708075,0.0001984883,0.0001009812,0.0002914185,0.000430308,0.0002152435,0.0001677397,0.000189965,0.000003580631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001138912,"about_ca_system_score_gemma":0.00006285933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006619322,"about_ca_topic_score_gemma":0.00001538958,"domain_scores_codex":[0.9982055,0.0001736098,0.0002961378,0.0003524897,0.000429464,0.0005427931],"domain_scores_gemma":[0.9988621,0.0003090169,0.0001623689,0.0001059913,0.0002155217,0.0003449438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001124215,0.0003609833,0.9164063,0.0002070683,0.001524052,0.000003164564,0.002098894,3.429532e-8,0.0008893208,0.00009767868,0.0002558492,0.07703246],"study_design_scores_gemma":[0.005123897,0.000954813,0.9814625,0.0001356877,0.003208499,0.000009970295,0.007371838,0.0001333552,0.001053216,0.0002104441,0.000149947,0.0001858364],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816463,0.01364377,0.000149282,0.001645994,0.0001667482,0.001965973,0.0002014859,0.00003301743,0.0005474405],"genre_scores_gemma":[0.9972635,0.001424344,0.00002094932,0.0005505895,0.0001745327,0.0002247098,0.000238651,0.00002536141,0.00007738188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07684662,"threshold_uncertainty_score":0.8094118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576064576053274,"score_gpt":0.2895247389265687,"score_spread":0.2737640931660359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}