{"id":"W2074129822","doi":"10.1038/nsmb740","title":"Regulation of the p300 HAT domain via a novel activation loop","year":2004,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":423,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Associazione Italiana per la Ricerca sul Cancro; Johns Hopkins University; Ellison Medical Foundation","keywords":"Coactivator; Histone acetyltransferase; Cell biology; Autophosphorylation; Regulation of gene expression; Histone; Biology; P300-CBP Transcription Factors; Chemistry; Gene; Kinase; Genetics; Transcription factor; Protein kinase A; Histone Acetyltransferases","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408535,0.0002011161,0.000182381,0.00009111387,0.0003278686,0.0004148378,0.0004943992,0.0003946398,0.00218922],"category_scores_gemma":[0.0002384591,0.0001727497,0.0001966055,0.00005881899,0.0003171923,0.0003184577,0.0003627552,0.0008380006,0.001046438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003730841,"about_ca_system_score_gemma":0.0001885296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003471699,"about_ca_topic_score_gemma":0.0005670816,"domain_scores_codex":[0.9999186,0.000009240703,0.000003353195,0.00002775196,0.0000212805,0.00001979197],"domain_scores_gemma":[0.9998721,0.00004437074,0.00001392803,0.00001750522,0.00001519111,0.00003687923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002130699,0.00003298901,0.0001975045,0.00001947534,0.000003185691,0.0001382533,0.00001958445,0.0003838864,0.9930016,0.001911117,0.0002382184,0.003841021],"study_design_scores_gemma":[0.00009884248,0.0001588708,0.004094938,0.000008252634,0.000009453312,0.0004209739,0.00003864004,0.01458,0.9728309,0.001924529,0.00580819,0.00002640097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392946,0.0009279614,0.05063896,0.000502875,0.0001768477,0.00005030529,0.0002554909,0.0009403802,0.007212577],"genre_scores_gemma":[0.9945186,0.00009880352,0.003127395,0.0000875997,0.00002000189,0.00001361963,0.0001220525,0.00002522313,0.001986694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00218922,"threshold_uncertainty_score":0.007323682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002208193570915296,"score_gpt":0.2334032035195154,"score_spread":0.2311950099486001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}