{"id":"W2074171009","doi":"10.3389/fonc.2013.00038","title":"Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology","year":2013,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":261,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"PKM2; Pyruvate dehydrogenase kinase; Angiogenesis; Cancer research; Citric acid cycle; Glycolysis; Cancer cell; Warburg effect; Pyruvate dehydrogenase complex; Anaerobic glycolysis; Mitochondrion; Pyruvate kinase; Biology; Cancer; Chemistry; Biochemistry; Cell biology; Internal medicine; Metabolism; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003765438,0.0002768076,0.0005629616,0.0002558634,0.00004952711,0.00001564626,0.0003755261,0.0006384256,0.0001622991],"category_scores_gemma":[0.0001252386,0.0002798927,0.0001257183,0.0002632753,0.0002418911,0.00001260658,0.0001486457,0.0003415872,0.00006671706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002695842,"about_ca_system_score_gemma":0.0006964871,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006407158,"about_ca_topic_score_gemma":0.0007420265,"domain_scores_codex":[0.997897,0.0002143849,0.0004644263,0.0006063452,0.0001166799,0.0007011874],"domain_scores_gemma":[0.9991488,0.00003082291,0.0001507467,0.000420566,0.00007284874,0.000176244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000631151,0.001129016,0.01119553,0.00002610513,0.0001446869,0.00005360829,0.0005981998,0.0003341728,0.8021215,0.0003177641,0.06478614,0.1186622],"study_design_scores_gemma":[0.003984218,0.0008228,0.00363849,0.000009254164,0.00002340547,0.00004773723,0.0005051733,0.0004351722,0.03214026,0.002150054,0.9558799,0.0003635217],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641029,0.0143249,0.0037882,0.001553213,0.006175829,0.0009257094,0.00002351768,0.00002569645,0.009080057],"genre_scores_gemma":[0.9656245,0.003675653,0.01868673,0.007195858,0.001528691,0.0007354073,0.0001522995,0.00008255628,0.002318318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8910938,"threshold_uncertainty_score":0.9999653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01013612311411879,"score_gpt":0.2716241621376089,"score_spread":0.2614880390234901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}