{"id":"W2074171743","doi":"10.7448/ias.15.6.18113","title":"Selection in culture of HIV resistance to dolutegravir by mutations at integrase positions R263K and H51Y that diminish viral replication fitness","year":2012,"lang":"en","type":"article","venue":"Journal of the International AIDS Society","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Dolutegravir; Integrase; Virology; Integrase inhibitor; Recombinant DNA; Viral replication; Virus; Resistance mutation; Mutation; Recombinant virus; Viral evolution; Drug resistance; Biology; Mutagenesis; Molecular biology; Viral load; Genetics; Human immunodeficiency virus (HIV); Gene; Reverse transcriptase; Antiretroviral therapy; Polymerase chain reaction; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002498056,0.0004622152,0.0005356999,0.000199848,0.0003545247,0.0004686782,0.0005696369,0.0002944104,0.001944488],"category_scores_gemma":[0.0003415512,0.0002398023,0.0003698934,0.0001482652,0.0001769151,0.0001582765,0.0004190121,0.0009371682,0.0009616566],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004491512,"about_ca_system_score_gemma":0.0003679961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003044593,"about_ca_topic_score_gemma":0.003776364,"domain_scores_codex":[0.999631,0.00008077258,0.00004253145,0.00007974298,0.0001128289,0.00005299676],"domain_scores_gemma":[0.9996932,0.00008619881,0.00004933627,0.00006560019,0.00006011337,0.00004567457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007925996,0.00004394056,0.0004653147,0.00002216371,0.000006813865,0.0001139933,0.00003034498,0.0001376963,0.9975884,0.0000551926,0.00009962875,0.001357322],"study_design_scores_gemma":[0.0000404164,0.0009545838,0.004284029,0.00001756331,0.00003675332,0.0008672234,0.00007541623,0.002023042,0.9859293,0.00003587794,0.005720041,0.00001563881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850358,0.001957828,0.006996823,0.0002494811,0.00009933219,0.0002738961,0.001094477,0.0001094817,0.004182963],"genre_scores_gemma":[0.963906,0.002093208,0.01796554,0.000267101,0.00005719041,0.0003115166,0.003535646,0.0001069775,0.01175678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044593,"threshold_uncertainty_score":0.006504953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183608156442615,"score_gpt":0.2826485326810176,"score_spread":0.2708124511165915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}