{"id":"W2074200299","doi":"10.1371/journal.pcbi.1003273","title":"Molecular Mechanical Differences between Isoforms of Contractile Actin in the Presence of Isoforms of Smooth Muscle Tropomyosin","year":2013,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Christie (Canada); McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Studienstiftung des Deutschen Volkes; Compute Canada; Canadian Institutes of Health Research; Mitacs; McGill University Health Centre; National Heart, Lung, and Blood Institute; Faculty of Medicine, McGill University; McGill University","keywords":"Tropomyosin; Myosin; Actin; Meromyosin; Actin remodeling; Biology; Gene isoform; Microfilament; Myosin light-chain kinase; Muscle contraction; Cell biology; Biophysics; Myosin head; Actin cytoskeleton; Chemistry; Biochemistry; Cytoskeleton; Anatomy; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001843809,0.0001024944,0.0005243255,0.0000898184,0.0000235972,0.000002493159,0.0001390586,0.00008498986,0.00003489835],"category_scores_gemma":[0.0002827705,0.00006000817,0.0001101305,0.0001623967,0.0002806743,0.0000467755,0.00005963626,0.0001332407,0.000002679682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001190364,"about_ca_system_score_gemma":0.0000542601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00021743,"about_ca_topic_score_gemma":0.000004497718,"domain_scores_codex":[0.9989418,0.0001049686,0.000438661,0.0001521932,0.0002089047,0.0001534079],"domain_scores_gemma":[0.9982928,0.001115751,0.0002207886,0.0001335594,0.0002090291,0.00002809276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005354735,0.001994076,0.4605304,0.0006024757,0.001052344,0.00001490356,0.004141444,0.0004350339,0.4563363,0.03818337,0.000283187,0.03589104],"study_design_scores_gemma":[0.001014165,0.000749724,0.9620008,0.00008793255,0.00008920488,0.000005813769,0.0009280039,0.001058463,0.01825238,0.01568368,0.0000477275,0.00008212266],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960504,0.0001786857,0.00215897,0.0007749933,0.00003561406,0.00043243,0.0000442012,0.000007033507,0.0003177193],"genre_scores_gemma":[0.998829,0.00002231517,0.0009523562,0.00008039946,0.00003348049,0.00003665972,0.00003715205,0.000004984737,0.00000366146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5014704,"threshold_uncertainty_score":0.2447062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02700578159234822,"score_gpt":0.2786322291784052,"score_spread":0.251626447586057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}