{"id":"W2074205615","doi":"10.1126/scisignal.2003350","title":"Cross-Species Protein Interactome Mapping Reveals Species-Specific Wiring of Stress Response Pathways","year":2013,"lang":"en","type":"article","venue":"Science Signaling","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Canadian Institute for Advanced Research; University of Toronto","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Human Genome Research Institute","keywords":"Interactome; Schizosaccharomyces pombe; Biology; Saccharomyces cerevisiae; Schizosaccharomyces; Protein–protein interaction; Yeast; Signal transduction; Computational biology; Genetics; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001876413,0.0002989122,0.0002261944,0.00117135,0.0002675481,0.000289707,0.0002408474,0.0002347275,0.00113298],"category_scores_gemma":[0.0005050686,0.0002071502,0.0003383429,0.0005796443,0.0001731967,0.0004169382,0.0006172215,0.0002371061,0.0001911546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002531708,"about_ca_system_score_gemma":0.0001333359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004388056,"about_ca_topic_score_gemma":0.0008529477,"domain_scores_codex":[0.9997928,0.00002744099,0.00001508385,0.0001015731,0.00004049745,0.00002255082],"domain_scores_gemma":[0.999584,0.00009819539,0.0001366248,0.00006339554,0.00005024272,0.00006749012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001806396,0.00002384686,0.008568249,0.00008625496,0.00006364671,0.0001284787,0.00004259237,0.0006779416,0.9856763,0.0004669961,0.00007126306,0.00401378],"study_design_scores_gemma":[0.00003907273,0.0002910957,0.4350368,0.00003316638,0.0002967343,0.002255175,0.0001937831,0.05219824,0.4990331,0.003315854,0.007262172,0.00004477143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924434,0.000257919,0.006084715,0.00002016657,0.000004165105,0.000009949369,0.0004961263,0.0001085929,0.0005751129],"genre_scores_gemma":[0.9908339,0.0001706582,0.006859186,0.00002577448,0.000003605589,0.00002400057,0.001770148,0.00003284324,0.0002798256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117135,"threshold_uncertainty_score":0.00379014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02388279375919261,"score_gpt":0.2460545747076827,"score_spread":0.22217178094849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}