{"id":"W2074246747","doi":"10.4161/cc.2.6.577","title":"Multiple Roles of Replication Forks in S Phase Checkpoints: Sensors, Effectors and Targets","year":2003,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Genome instability; DNA re-replication; Cell biology; DNA replication; G2-M DNA damage checkpoint; Effector; Checkpoint Kinase 2; DNA damage; Control of chromosome duplication; Replication (statistics); Cell cycle checkpoint; Origin recognition complex; Genetics; Eukaryotic DNA replication; DNA; Cell cycle; Gene; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005514312,0.0007706871,0.001156017,0.0007641918,0.000428586,0.00147447,0.0005422059,0.0008351898,0.002183603],"category_scores_gemma":[0.0002566379,0.00029714,0.0003026155,0.0007941179,0.0004633858,0.002523302,0.0006304829,0.0008117309,0.001054843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005644377,"about_ca_system_score_gemma":0.0004031495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001655721,"about_ca_topic_score_gemma":0.0003861554,"domain_scores_codex":[0.9997708,0.00002798915,0.00002316104,0.00006485078,0.00008307287,0.00003018653],"domain_scores_gemma":[0.9998322,0.00005423936,0.00002728008,0.00001081364,0.00004020584,0.00003527202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007408967,0.0001065706,0.001070496,0.004266521,0.00007121951,0.0009945506,0.0002069167,0.001694612,0.7109059,0.011424,0.001275329,0.2672431],"study_design_scores_gemma":[0.0001111439,0.001054946,0.01027285,0.0008393889,0.0004225896,0.00729878,0.0008875045,0.003280082,0.5877205,0.03656533,0.3513989,0.0001480232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.05345817,0.9201752,0.01668712,0.001834921,0.0003682515,0.00003722147,0.0001348375,0.0001951201,0.007109243],"genre_scores_gemma":[0.28129,0.689375,0.01516662,0.0005812134,0.000621696,0.0000523732,0.0002243262,0.00005686391,0.01263202],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002183603,"threshold_uncertainty_score":0.007304907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005248611004316858,"score_gpt":0.2376233366975931,"score_spread":0.2323747256932763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}