{"id":"W2074246747","doi":"10.4161/cc.2.6.577","title":"Multiple Roles of Replication Forks in S Phase Checkpoints: Sensors, Effectors and Targets","year":2003,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Genome instability; DNA re-replication; Cell biology; DNA replication; G2-M DNA damage checkpoint; Effector; Checkpoint Kinase 2; DNA damage; Control of chromosome duplication; Replication (statistics); Cell cycle checkpoint; Origin recognition complex; Genetics; Eukaryotic DNA replication; DNA; Cell cycle; Gene; Virology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001999228,0.00007774644,0.00009630034,0.000026357,0.00001648605,0.000003905812,0.00004894429,0.00009205507,0.000008534401],"category_scores_gemma":[0.0001578377,0.00007939928,0.00003187511,0.00004390044,0.0000259893,0.0000025248,0.0000250892,0.00003849727,0.000002329111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006598315,"about_ca_system_score_gemma":0.00001135084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001036784,"about_ca_topic_score_gemma":0.00002065192,"domain_scores_codex":[0.9993888,0.00005296474,0.0001375698,0.0002577316,0.00004545388,0.000117526],"domain_scores_gemma":[0.9995481,0.00001255806,0.00005967207,0.0003196732,0.00002076921,0.00003917916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000325961,0.0001215577,0.003505869,0.00002456071,0.000004591999,9.772747e-7,0.00004762894,0.00004132762,0.9949822,0.00002824055,0.00007226317,0.001138176],"study_design_scores_gemma":[0.001207592,0.0001436434,0.0008625613,0.000006983741,0.000004787346,0.00000272222,0.00005363182,0.0005860261,0.9949255,0.00012747,0.001995743,0.00008331681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976322,0.000645607,0.0005784361,0.00000823586,0.00003202099,0.0001810409,0.000006223876,0.000007489578,0.0009087507],"genre_scores_gemma":[0.9983007,0.00005331821,0.00141856,0.00002140849,0.00001278758,0.00001568084,0.00003639377,0.00001315766,0.0001279811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002643308,"threshold_uncertainty_score":0.3237809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005248611004316858,"score_gpt":0.2376233366975931,"score_spread":0.2323747256932763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}