{"id":"W2074251257","doi":"10.3390/md10061307","title":"Marine Cyclotripeptide X-13 Promotes Angiogenesis in Zebrafish and Human Endothelial Cells via PI3K/Akt/eNOS Signaling Pathways","year":2012,"lang":"en","type":"article","venue":"Marine Drugs","topic":"Marine Sponges and Natural Products","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Science and Technology Planning Project of Guangdong Province; Fundamental Research Funds for the Central Universities; National Natural Science Foundation of China","keywords":"Zebrafish; Enos; Angiogenesis; Protein kinase B; PI3K/AKT/mTOR pathway; Cell biology; Signal transduction; Biology; Chemistry; Cancer research; Biochemistry; Nitric oxide; Endocrinology; Nitric oxide synthase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005743594,0.0002087388,0.00008485805,0.0001290744,0.00008414163,0.00009400398,0.00005558055,0.00007350199,0.001400261],"category_scores_gemma":[0.00004078234,0.0000661395,0.0001404426,0.00006797245,0.0001002695,0.00008202015,0.0001134138,0.0002362851,0.0001341473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001396925,"about_ca_system_score_gemma":0.0001699349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001026884,"about_ca_topic_score_gemma":0.00205396,"domain_scores_codex":[0.9999771,0.000004151312,0.000002427705,0.000004533552,0.000005906943,0.000005849562],"domain_scores_gemma":[0.9999815,0.000002172052,0.000006103032,0.000001257497,0.00000222513,0.00000668974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002340763,0.00003165414,0.0002750405,0.00004350739,0.000005293172,0.00007402676,0.00001145333,0.00007746591,0.9970631,0.00007081463,0.00006858283,0.002044975],"study_design_scores_gemma":[0.00007952192,0.001141112,0.01531312,0.00001273736,0.0000306302,0.0002409799,0.00003841166,0.0007873981,0.9788738,0.00005245503,0.003423257,0.00000668681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952092,0.001533161,0.000779622,0.00008283654,0.00001458894,0.00002543929,0.0002109845,0.00003502352,0.002109203],"genre_scores_gemma":[0.9951783,0.001398482,0.0009848742,0.00004168261,0.000005214375,0.00003010417,0.0002396965,0.000003970498,0.002117595],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001400261,"threshold_uncertainty_score":0.004684329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007051423743195279,"score_gpt":0.2132455136788544,"score_spread":0.2061940899356592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}