{"id":"W2074253758","doi":"10.1038/labinvest.3700748","title":"Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities","year":2008,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":127,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Multiple Sclerosis Society of Canada; Nationale Genossenschaft für die Lagerung radioaktiver Abfälle; Stichting voor de Technische Wetenschappen; Hospital for Sick Children; Multiple Sclerosis Society; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Citrullination; Citrulline; Myelin; Myelin basic protein; Arginine; Pathogenesis; Chemistry; Immunogold labelling; Biochemistry; Biology; Immunology; Endocrinology; Amino acid; Antibody; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746152,0.0003768178,0.0002381815,0.0005500996,0.0001900955,0.0005028361,0.0002397342,0.0002631322,0.001361251],"category_scores_gemma":[0.0003110586,0.0001892745,0.0003756872,0.0003318944,0.0002138182,0.0003577868,0.0003225364,0.0003476418,0.0004507332],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003816888,"about_ca_system_score_gemma":0.000198961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002682,"about_ca_topic_score_gemma":0.0008416721,"domain_scores_codex":[0.9998825,0.00001865273,0.00001263169,0.00002730488,0.00001883739,0.0000400636],"domain_scores_gemma":[0.9997737,0.00006005736,0.0000441624,0.00002770008,0.0000393443,0.00005504649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006655201,0.00001511518,0.001148674,0.00003416949,0.00001456788,0.00008424347,0.00003168701,0.0000611611,0.9965198,0.0001743519,0.0000236803,0.001226958],"study_design_scores_gemma":[0.0000290559,0.0001789235,0.02012858,0.000004363236,0.00003977118,0.0006586505,0.00008870134,0.000865947,0.9757792,0.000142372,0.002075942,0.000008479798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952098,0.0009481118,0.002330896,0.00004420547,0.00001659657,0.000009420599,0.0003823394,0.00002631596,0.001032439],"genre_scores_gemma":[0.9867156,0.0006533267,0.004720485,0.00005439077,0.00002251597,0.00003071692,0.002741621,0.00003380087,0.005027713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001361251,"threshold_uncertainty_score":0.004553854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02017630524739926,"score_gpt":0.2737501919746091,"score_spread":0.2535738867272099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}