{"id":"W2074254682","doi":"10.1038/sj.ijir.3901283","title":"High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients","year":2004,"lang":"en","type":"article","venue":"International Journal of Impotence Research","topic":"Phosphodiesterase function and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":73,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Bayer Canada; National Institutes of Health","keywords":"Vardenafil; Tadalafil; Sildenafil; cGMP-specific phosphodiesterase type 5; Medicine; Phosphodiesterase; Erectile dysfunction; Pharmacology; Enzyme; Internal medicine; Endocrinology; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001002458,0.0001089786,0.0001757179,0.0001773526,0.00007936852,0.00003794346,0.0003152569,0.0001211891,0.000007847],"category_scores_gemma":[0.0007643874,0.00008186821,0.00009631332,0.0001458744,0.0003624439,0.00004260851,0.0001161734,0.0002381235,3.60507e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001179996,"about_ca_system_score_gemma":0.0002027896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003137779,"about_ca_topic_score_gemma":0.0000661864,"domain_scores_codex":[0.9983265,0.00008667362,0.0005035053,0.0001973728,0.0006902432,0.0001956482],"domain_scores_gemma":[0.9976497,0.0001385984,0.0003432718,0.0001496875,0.001649726,0.00006899258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001360997,0.0003743573,0.09578001,0.00003002047,0.00008907119,0.000003980672,0.0001398834,0.0005375081,0.899874,0.0002194813,0.0002451215,0.001345621],"study_design_scores_gemma":[0.002133535,0.0005994749,0.4795305,0.0001023562,0.000004801841,0.00002414791,0.00003712625,0.00003312252,0.5163523,0.0009603779,0.0001522545,0.00007003485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985533,0.0002017929,0.0004538058,0.0002789265,0.0002565022,0.0002001467,0.00003702611,0.000001512275,0.00001696104],"genre_scores_gemma":[0.9992913,0.0001798064,0.0002416652,0.00003069927,0.0001530392,0.000008745979,0.00003015585,0.00001039027,0.00005421041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3837505,"threshold_uncertainty_score":0.3338489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802385797755471,"score_gpt":0.3633812176125949,"score_spread":0.3453573596350402,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}