{"id":"W2074267082","doi":"10.1021/bi048524p","title":"Binding of Antitumor Antibiotic Daunomycin to Histones in Chromatin and in Solution","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Chromatin; Histone; Linker; Histone-modifying enzymes; Chemistry; DNA; Linker DNA; Biophysics; Biochemistry; Histone H1; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001091749,0.0001070424,0.000137767,0.00006264007,0.00001741039,0.000007692719,0.00010213,0.000109562,0.000001840409],"category_scores_gemma":[0.00004646292,0.0001216453,0.00002508979,0.0001176673,0.00004874431,0.000002158045,0.00009107024,0.00005009663,0.000001706081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006101572,"about_ca_system_score_gemma":0.00007804366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008946308,"about_ca_topic_score_gemma":0.0001083626,"domain_scores_codex":[0.9992917,0.00000773301,0.0002261968,0.0002506583,0.00005600416,0.0001677328],"domain_scores_gemma":[0.9996872,0.000003079196,0.00006456571,0.0001817203,0.00001686191,0.0000465723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002064038,0.00006020135,0.01304514,0.00009538748,0.000003893644,0.000004437701,0.0000445919,0.0001655035,0.9863682,0.00001279125,0.00001709817,0.0001620989],"study_design_scores_gemma":[0.0006107222,0.00005730601,0.02714707,0.0001122336,0.000002944615,0.00001705477,0.00008738007,0.00009458869,0.9716743,0.00002316425,0.0000295834,0.00014364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990393,0.0003884909,0.00009905004,0.00009299147,0.00003488092,0.0001006844,0.00001551252,0.00000355923,0.000225564],"genre_scores_gemma":[0.9972683,0.00006146999,0.002499798,0.00002428152,0.00002709826,0.000003207798,0.00004875495,0.0000113462,0.00005580903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0146939,"threshold_uncertainty_score":0.4960551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005250507166809173,"score_gpt":0.2212175044036163,"score_spread":0.2159669972368071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}