{"id":"W2074267082","doi":"10.1021/bi048524p","title":"Binding of Antitumor Antibiotic Daunomycin to Histones in Chromatin and in Solution","year":2004,"lang":"en","type":"article","venue":"Biochemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"","keywords":"Chromatin; Histone; Linker; Histone-modifying enzymes; Chemistry; DNA; Linker DNA; Biophysics; Biochemistry; Histone H1; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002155214,0.0002250695,0.0002801591,0.0001689956,0.0003045938,0.0003885927,0.0003522213,0.0003435487,0.001111793],"category_scores_gemma":[0.000248615,0.000191069,0.0001643835,0.00022024,0.000351287,0.0002621568,0.000237476,0.0006173271,0.0002734702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004498068,"about_ca_system_score_gemma":0.0002496244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00292986,"about_ca_topic_score_gemma":0.00283847,"domain_scores_codex":[0.9997572,0.00005676795,0.00001143558,0.00006704361,0.00005263392,0.00005486854],"domain_scores_gemma":[0.9998642,0.00006029483,0.00001612906,0.00001414181,0.00001569105,0.00002954561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008202469,0.00002091988,0.0003327949,0.00005357353,0.00001089841,0.00002505879,0.00006654374,0.0001759891,0.9980127,0.0002211697,0.00003376579,0.0009646776],"study_design_scores_gemma":[0.00001729903,0.0002221769,0.00331317,0.0000105103,0.00001291598,0.00006130239,0.00008471881,0.002424535,0.9913697,0.0001133861,0.002361423,0.000008857038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880674,0.002122438,0.006513102,0.0001412847,0.00003633749,0.00002605966,0.0001611376,0.00004331622,0.002888819],"genre_scores_gemma":[0.9918793,0.001186749,0.003701036,0.00007405037,0.00001687265,0.00001884554,0.0004668314,0.00001853851,0.002637737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00292986,"threshold_uncertainty_score":0.005825639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005250507166809173,"score_gpt":0.2212175044036163,"score_spread":0.2159669972368071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}