{"id":"W2074271273","doi":"10.4161/chan.22209","title":"Is ZD7288 a selective blocker of hyperpolarization-activated cyclic nucleotide-gated channel currents?","year":2012,"lang":"en","type":"article","venue":"Channels","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Natural Science Foundation of China; University of Lethbridge","keywords":"Hyperpolarization (physics); HCN channel; Chemistry; Cyclic nucleotide; Biophysics; Channel blocker; Potassium channel blocker; Channel (broadcasting); Potassium channel; Ion channel; Cell biology; Nucleotide; Pharmacology; Biochemistry; Biology; Computer network; Stereochemistry; Computer science; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001431789,0.0001964641,0.0001871031,0.0001158755,0.000102634,0.00001341909,0.0001096082,0.0002205193,0.0001320268],"category_scores_gemma":[0.00009034945,0.000192484,0.0001130057,0.0003415681,0.00006363139,0.00002164498,0.00006285823,0.00009609848,0.00004802762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002339567,"about_ca_system_score_gemma":0.00003507856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001348655,"about_ca_topic_score_gemma":5.455324e-7,"domain_scores_codex":[0.9988863,0.00006284517,0.0002628407,0.0002758141,0.0001718971,0.0003402825],"domain_scores_gemma":[0.999181,0.000009952673,0.0001681631,0.0002333259,0.0002703786,0.0001371247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001815639,0.0003927681,0.006597813,0.00004060815,0.0001875123,2.841911e-7,0.001577895,0.0003767087,0.9803292,0.0001015988,0.009247489,0.0009666073],"study_design_scores_gemma":[0.0006667494,0.0001404816,0.003293004,0.00002280549,0.00002716218,0.000008503803,0.0002101783,0.00167699,0.9811124,0.00006433496,0.01252501,0.0002524411],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913925,0.000340092,0.00532987,0.0001384536,0.00158462,0.0002960254,0.00004261278,0.00003912116,0.0008366843],"genre_scores_gemma":[0.9972485,0.00005385351,0.00006600279,0.0002544232,0.0008936573,0.00001899736,0.0003264392,0.00003749063,0.001100617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005855998,"threshold_uncertainty_score":0.7849269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02158527674941745,"score_gpt":0.2640238022101872,"score_spread":0.2424385254607697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}