{"id":"W2074286655","doi":"10.1021/bi0523761","title":"Rational Design of Peptide Inhibitors of the Sarcoplasmic Reticulum Calcium Pump","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Peptide; Chemistry; Transmembrane domain; SERCA; Transmembrane protein; Phospholamban; Peptide sequence; Biochemistry; Amino acid; Biophysics; Endoplasmic reticulum; Biology; Enzyme; Receptor; ATPase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002591689,0.0007323875,0.0005860631,0.0003978245,0.0001656894,0.0005491297,0.0006328193,0.0004228715,0.001223808],"category_scores_gemma":[0.000249407,0.0003072137,0.0002746759,0.000235467,0.0002097464,0.0002794189,0.0002798786,0.0007395811,0.0004970382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003418648,"about_ca_system_score_gemma":0.0002429054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002117339,"about_ca_topic_score_gemma":0.0004869611,"domain_scores_codex":[0.9998829,0.00002419033,0.0000151422,0.00002291223,0.00002606868,0.00002869935],"domain_scores_gemma":[0.9998887,0.00002237159,0.00003451853,0.000005199713,0.00001719082,0.00003205041],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009178373,0.0006627507,0.000358688,0.0004903334,0.0001033705,0.0005429126,0.00005009176,0.007959197,0.9650499,0.001624762,0.0005540419,0.02168612],"study_design_scores_gemma":[0.001931764,0.006241363,0.001787286,0.00009664654,0.000264773,0.001077845,0.00006462161,0.01669739,0.9355057,0.0006890112,0.03557447,0.00006913383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9557804,0.01578155,0.01838513,0.000315748,0.0002017013,0.001006094,0.001057236,0.0002536473,0.007218455],"genre_scores_gemma":[0.961729,0.01158215,0.02145433,0.0003029782,0.00006023467,0.0006175222,0.001245346,0.00005769941,0.002950769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223808,"threshold_uncertainty_score":0.004094005,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074477711283207,"score_gpt":0.2179527626659004,"score_spread":0.2072079855530683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}