{"id":"W2074329146","doi":"10.1038/nature09806","title":"The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset","year":2011,"lang":"en","type":"article","venue":"Nature","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":558,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; National Cancer Institute; Canadian Institutes of Health Research; National Human Genome Research Institute; Howard Hughes Medical Institute","keywords":"Biology; Chromatin immunoprecipitation; Zebrafish; Melanoma; Cancer research; Histone methyltransferase; Chromatin; V600E; Histone; EZH2; Carcinogenesis; Mutation; Genetics; Gene; Gene expression; Promoter","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001529639,0.0002741808,0.0002353206,0.0003893289,0.0001659674,0.0003561835,0.0001804608,0.0003009324,0.001886756],"category_scores_gemma":[0.0002589145,0.0002795236,0.0002529894,0.0002249567,0.0001507231,0.0002108579,0.0002933085,0.0005973374,0.0005101193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002877407,"about_ca_system_score_gemma":0.0001791057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008618294,"about_ca_topic_score_gemma":0.0009439128,"domain_scores_codex":[0.9998801,0.00001540382,0.00000826044,0.00002969545,0.00003581279,0.0000308614],"domain_scores_gemma":[0.9997464,0.00003250341,0.0001043472,0.000025462,0.00002557192,0.00006567797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003625361,0.00003656013,0.01033412,0.00003553347,0.00002154788,0.0006745418,0.00002656675,0.00009893694,0.9837556,0.000222838,0.0002559593,0.004175304],"study_design_scores_gemma":[0.00006349594,0.0006348616,0.3164237,0.00001515456,0.0001326162,0.009950412,0.0001505368,0.002329312,0.6607674,0.0005407649,0.008969769,0.00002196631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943715,0.001757104,0.001660817,0.0001201251,0.00005181272,0.00001542725,0.0003789473,0.0002045119,0.001439762],"genre_scores_gemma":[0.9971666,0.0004151019,0.0003512854,0.00001993452,0.00001141227,0.000007510654,0.0001923959,0.00002618378,0.001809546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001886756,"threshold_uncertainty_score":0.006311834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346159658009512,"score_gpt":0.2619174620599327,"score_spread":0.2484558654798376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}