{"id":"W2074331690","doi":"10.1016/j.ejmech.2013.03.055","title":"Novel 3,5-bis(arylidene)-4-piperidone dimers: Potent cytotoxins against colon cancer cells","year":2013,"lang":"en","type":"article","venue":"European Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxicity; Chemistry; Curcumin; Apoptosis; Stereochemistry; Cytotoxic T cell; Flow cytometry; Cell culture; Amide; IC50; Colorectal cancer; In vitro; Structure–activity relationship; Biochemistry; Cancer; Molecular biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006455664,0.000323662,0.000515857,0.00002815511,0.0001053191,0.00005823137,0.0006448238,0.0001103388,0.006674576],"category_scores_gemma":[0.0002639662,0.0002221556,0.0002794229,0.0000982722,0.0002174113,0.0001453102,0.0001314352,0.0008047995,0.00007798676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001679915,"about_ca_system_score_gemma":0.0001140371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000377462,"about_ca_topic_score_gemma":6.170343e-7,"domain_scores_codex":[0.9978544,0.00006777715,0.0007699721,0.0003071296,0.0005823763,0.0004183799],"domain_scores_gemma":[0.9980557,0.0001626718,0.0007586929,0.0002874677,0.0002602604,0.0004751814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009973665,0.0002938377,0.0002702217,0.0001157755,0.0001161609,0.0002548202,0.00006485762,0.00002732588,0.970318,3.095805e-7,0.004618039,0.02382093],"study_design_scores_gemma":[0.001167178,0.00009621269,0.001871368,0.0005474478,0.0000833304,0.0002740379,0.0005493012,0.00005194581,0.9788507,0.000002771891,0.01620319,0.0003025238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.94429,0.001041727,0.000121944,0.0009516029,0.0002317606,0.00004747996,0.0000234682,0.00003278416,0.05325921],"genre_scores_gemma":[0.9945858,0.000560122,0.0004300774,0.000469358,0.002146429,0.000004330893,0.000004721574,0.00004121738,0.001757944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05150126,"threshold_uncertainty_score":0.9942334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01949824085559938,"score_gpt":0.2200363629762063,"score_spread":0.200538122120607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}