{"id":"W2074360408","doi":"10.1007/s10534-008-9196-x","title":"Can copper binding to the prion protein generate a misfolded form of the protein?","year":2009,"lang":"en","type":"article","venue":"BioMetals","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Bone and Joint Health Institute; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Western Canada Research Grid","keywords":"Cleavage (geology); Chemistry; Biophysics; Beta sheet; Crystallography; Molecular dynamics; Protein structure; Protein folding; Redox; Prion protein; Stereochemistry; Biochemistry; Biology; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003340293,0.0001583515,0.0001439572,0.00005932726,0.0001732318,0.0000418426,0.000435314,0.00009233475,0.00002182529],"category_scores_gemma":[0.0001269853,0.00008182038,0.0001729098,0.000383355,0.00004432895,0.000003955101,0.0001399793,0.00005783731,0.000009438782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001822619,"about_ca_system_score_gemma":0.00009525113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002422886,"about_ca_topic_score_gemma":0.0000225079,"domain_scores_codex":[0.9989129,0.00008941082,0.0002405726,0.0002738053,0.0002110387,0.0002722909],"domain_scores_gemma":[0.9991378,0.000002958139,0.0001381174,0.0005532764,0.00007469027,0.0000932262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004735489,0.00003413167,0.00005950881,0.00001353347,0.00003013022,5.189088e-7,0.00005483626,0.000006277338,0.9706021,0.0001136696,0.000695798,0.02834213],"study_design_scores_gemma":[0.0002517584,0.0002292543,0.0009727188,0.00005513991,0.00001809735,0.000003129644,0.00002928094,0.0000113334,0.9535933,0.0002195788,0.0444708,0.0001456803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908549,0.001771516,0.0001140083,0.00533719,0.0000694715,0.001691468,0.00005581974,0.00001061949,0.00009506222],"genre_scores_gemma":[0.9973447,0.00004956127,0.0005144306,0.0006225209,0.0001563906,0.0001289609,0.00001993185,0.00001458025,0.001148935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.043775,"threshold_uncertainty_score":0.3336538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01261904398452873,"score_gpt":0.2502404240255535,"score_spread":0.2376213800410247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}