{"id":"W2074443790","doi":"10.1016/j.pep.2009.02.015","title":"Clinical grade production and characterization of a fusion protein comprised of the chemokine CCL2-ligand genetically fused to a mutated and truncated form of the Shiga A1 subunit","year":2009,"lang":"en","type":"article","venue":"Protein Expression and Purification","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Fusion protein; Biology; Population; Chemokine; Molecular biology; Inclusion bodies; Biochemistry; Escherichia coli; Receptor; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005283552,0.0003955135,0.0003452596,0.0003045738,0.0002907363,0.0004980177,0.0003569176,0.000538271,0.002631739],"category_scores_gemma":[0.0007562425,0.0001928708,0.0002920361,0.0003630847,0.0003232716,0.0001427796,0.0002458739,0.0006846971,0.002151551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000539699,"about_ca_system_score_gemma":0.000807107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00125828,"about_ca_topic_score_gemma":0.0009980506,"domain_scores_codex":[0.9996732,0.00006454362,0.00002842094,0.00004269426,0.0001139521,0.00007728794],"domain_scores_gemma":[0.9996893,0.00004523169,0.00002786221,0.00005568408,0.00009630471,0.00008560512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000529036,0.000236326,0.001352094,0.0001024613,0.00001223811,0.0003914992,0.00006695047,0.0001333099,0.9911377,0.000272956,0.001161894,0.004603465],"study_design_scores_gemma":[0.0008600879,0.005555033,0.02357132,0.00004486289,0.0001433239,0.007514892,0.0002114297,0.002579699,0.9003289,0.0004110031,0.05874975,0.00002969773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649997,0.002732385,0.02007741,0.001709696,0.0002125684,0.001607983,0.003213132,0.0002478509,0.005199371],"genre_scores_gemma":[0.9675259,0.00133801,0.01295201,0.0003661413,0.00008816684,0.0003946694,0.01035959,0.00006183418,0.006913873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002631739,"threshold_uncertainty_score":0.008804083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699092237563501,"score_gpt":0.2506800617641561,"score_spread":0.2336891393885211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}