{"id":"W2074443790","doi":"10.1016/j.pep.2009.02.015","title":"Clinical grade production and characterization of a fusion protein comprised of the chemokine CCL2-ligand genetically fused to a mutated and truncated form of the Shiga A1 subunit","year":2009,"lang":"en","type":"article","venue":"Protein Expression and Purification","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Fusion protein; Biology; Population; Chemokine; Molecular biology; Inclusion bodies; Biochemistry; Escherichia coli; Receptor; Recombinant DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003806977,0.0001272829,0.0002339545,0.00007790794,0.0001497338,0.000009813254,0.000107023,0.0001863088,0.00002487924],"category_scores_gemma":[0.0002404075,0.00007882532,0.00004696807,0.000223134,0.0002001109,0.00009811501,0.00005676867,0.0001936614,0.00000101182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008825633,"about_ca_system_score_gemma":0.00002731811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001390215,"about_ca_topic_score_gemma":0.000001721243,"domain_scores_codex":[0.998673,0.0003014879,0.0005881042,0.0002550068,0.00007623173,0.0001061474],"domain_scores_gemma":[0.9989258,0.00002554815,0.0005248584,0.0002967496,0.0002038038,0.00002322815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007159146,0.0002229207,0.001216911,0.00006200553,0.00001311263,2.033597e-8,0.0007232168,4.104116e-7,0.9874257,0.00009126744,0.0000366729,0.009491807],"study_design_scores_gemma":[0.0007840282,0.0002497975,0.1949638,0.0003048049,0.00002166532,0.000005230924,0.00006773344,0.00005156255,0.8026292,0.0001114983,0.0007434427,0.00006725422],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958141,0.000163997,0.0003209306,0.00156269,0.0002534943,0.001835614,0.00000596265,0.00001735181,0.0000258819],"genre_scores_gemma":[0.9988351,0.00009324204,0.0001351447,0.00005737455,0.00001552929,0.00004923939,0.00004673682,0.000007757503,0.0007598713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1937469,"threshold_uncertainty_score":0.3214403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699092237563501,"score_gpt":0.2506800617641561,"score_spread":0.2336891393885211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}