{"id":"W2074446289","doi":"10.1021/cb400407c","title":"Fluorescence Linked Enzyme Chemoproteomic Strategy for Discovery of a Potent and Selective DAPK1 and ZIPK Inhibitor","year":2013,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"Phosphorylation; Myosin; Biology; Cell biology; Serine; Biochemistry; Scaffold protein; Kinase; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008167682,0.0001384399,0.0001939407,0.00002483185,0.00003329707,0.00001602429,0.00007599909,0.0002516983,0.000002794686],"category_scores_gemma":[0.0001330907,0.0001175468,0.00004370866,0.00004231553,0.0002379948,0.000008754329,0.0001073219,0.00007489262,7.986396e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008421764,"about_ca_system_score_gemma":0.00003997593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002695046,"about_ca_topic_score_gemma":0.000001129394,"domain_scores_codex":[0.9991793,0.00002700756,0.0002064737,0.0003482651,0.00003651902,0.0002024513],"domain_scores_gemma":[0.9995834,0.0000306612,0.00009103194,0.0001322979,0.00009531555,0.00006730916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001031361,0.00002754118,0.0003155804,0.00003677214,0.00002870346,1.579649e-7,0.0000131805,0.000001085601,0.9924797,0.0003828558,0.0001079379,0.006503327],"study_design_scores_gemma":[0.0007147765,0.0002745613,0.0006523111,0.00001565827,0.00001190705,0.00001040423,0.00002041884,0.0001549231,0.9958158,0.002027197,0.0001594354,0.0001426576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968429,0.0008791499,0.001462254,0.0001998384,0.00002088024,0.0005205604,0.00003017867,0.000007425224,0.00003677969],"genre_scores_gemma":[0.9973294,0.00009208519,0.002046695,0.0001005159,0.0001357344,0.0001130208,0.0001305935,0.00001139649,0.00004054603],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00636067,"threshold_uncertainty_score":0.479342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01080445808744117,"score_gpt":0.2427233509649522,"score_spread":0.231918892877511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}