{"id":"W2074517667","doi":"10.1016/j.bpc.2009.05.007","title":"Binding interactions in early- and late-stage amyloid aggregates of TTR(105–115)","year":2009,"lang":"en","type":"article","venue":"Biophysical Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"York University","funders":"","keywords":"Chemistry; Fibril; Transthyretin; Peptide; Hydrogen bond; Amide; Amyloid (mycology); Crystallography; Nuclear magnetic resonance spectroscopy; Chemical shift; Biophysics; Two-dimensional nuclear magnetic resonance spectroscopy; Side chain; Molecular dynamics; Amyloid fibril; Stereochemistry; Biochemistry; Molecule; Amyloid β; Computational chemistry; Physical chemistry; Polymer; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004232621,0.0003663297,0.0003847595,0.0002967027,0.0008105641,0.0004903913,0.0006368221,0.0006384611,0.003279845],"category_scores_gemma":[0.0006855485,0.0002257835,0.0004396088,0.0002153868,0.0002099876,0.0004153441,0.0003329926,0.0009841851,0.0009054344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006972586,"about_ca_system_score_gemma":0.000208605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004951511,"about_ca_topic_score_gemma":0.003265648,"domain_scores_codex":[0.9995093,0.00009746456,0.00002705858,0.0001015365,0.00008747605,0.0001772123],"domain_scores_gemma":[0.9996818,0.0001103468,0.00004152218,0.00002222764,0.00006106067,0.00008312174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001071676,0.0002292079,0.001379122,0.00008429886,0.00007354683,0.0005449904,0.0002920455,0.0008086206,0.9895847,0.0009718775,0.001107478,0.003852505],"study_design_scores_gemma":[0.0001024209,0.000839114,0.03219157,0.00005304122,0.0001263216,0.002028274,0.0003962853,0.01657232,0.9381268,0.0006481101,0.008813325,0.0001022961],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940584,0.001101866,0.001648353,0.0001337583,0.00005437694,0.00001279489,0.000134129,0.00004334658,0.002812952],"genre_scores_gemma":[0.9952984,0.0002400778,0.000925385,0.000260773,0.00001666804,0.00001053729,0.0004646959,0.00001913976,0.002764373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004951511,"threshold_uncertainty_score":0.01097214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247082295696253,"score_gpt":0.3135294994672044,"score_spread":0.2910586765102419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}