{"id":"W2074519205","doi":"10.1074/jbc.m500540200","title":"Glucose-dependent Insulinotropic Polypeptide (GIP) Stimulation of Pancreatic β-Cell Survival Is Dependent upon Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B (PKB) Signaling, Inactivation of the Forkhead Transcription Factor Foxo1, and Down-regulation of bax Expression","year":2005,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":241,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; University of Bristol; University of Dundee; Canadian Diabetes Association","keywords":"FOXO1; Endocrinology; Internal medicine; Protein kinase B; Biology; Phosphatidylinositol; PI3K/AKT/mTOR pathway; Transcription factor; Kinase; Signal transduction; Chemistry; Cell biology; Medicine; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008870355,0.0007157834,0.0002571233,0.0002009047,0.0001105377,0.0001752773,0.00009634281,0.0001591031,0.0009640101],"category_scores_gemma":[0.00005392694,0.0001293946,0.0003563178,0.0001892544,0.0002548268,0.0001181523,0.0002218109,0.0007002348,0.0002615058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001522856,"about_ca_system_score_gemma":0.0001307068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001638627,"about_ca_topic_score_gemma":0.0003290561,"domain_scores_codex":[0.9999114,0.00001135728,0.000007587691,0.00002420667,0.00002160003,0.00002382034],"domain_scores_gemma":[0.9999353,0.000006992048,0.00002123224,0.000009712739,0.000005227397,0.00002153279],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001900058,0.00003287992,0.0001588135,0.00003891717,0.000005661667,0.00005466773,0.000006704238,0.00001738738,0.9983236,0.00001928955,0.00002674026,0.001125281],"study_design_scores_gemma":[0.00004821476,0.0007653546,0.01572907,0.00001123738,0.00003555696,0.0003871635,0.00003038046,0.0002204518,0.9806346,0.00005300129,0.002080323,0.000004756429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932036,0.00240878,0.002377726,0.0001213137,0.0000595774,0.0000280753,0.0004391821,0.0001369443,0.001224779],"genre_scores_gemma":[0.991647,0.003179035,0.00234629,0.00008645569,0.0000295088,0.00006309088,0.001078453,0.00003852489,0.001531586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009640101,"threshold_uncertainty_score":0.003224969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01567837949438396,"score_gpt":0.2329558143368504,"score_spread":0.2172774348424664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}