{"id":"W2074553306","doi":"10.1124/jpet.111.182600","title":"Ginseng (Panax quinquefolius) Attenuates Leptin-Induced Cardiac Hypertrophy through Inhibition of p115Rho Guanine Nucleotide Exchange Factor-RhoA/Rho-Associated, Coiled-Coil Containing Protein Kinase-Dependent Mitogen-Activated Protein Kinase Pathway Activation","year":2011,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Ginseng Biological Effects and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"RHOA; Protein kinase A; Rho-associated protein kinase; MAPK/ERK pathway; Kinase; Leptin; Guanine nucleotide exchange factor; Chemistry; p38 mitogen-activated protein kinases; Internal medicine; Endocrinology; Cell biology; Biology; Signal transduction; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116699,0.0005636353,0.0004158655,0.0002462429,0.000207454,0.0001888943,0.0001934012,0.0002240657,0.00105483],"category_scores_gemma":[0.0001190573,0.0001747465,0.0002364519,0.0001355001,0.0002127003,0.0002680033,0.0001534291,0.000689305,0.0001779356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001539013,"about_ca_system_score_gemma":0.0002072285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007402191,"about_ca_topic_score_gemma":0.001408347,"domain_scores_codex":[0.9999379,0.00001656068,0.000005243402,0.0000103168,0.00001063514,0.00001932646],"domain_scores_gemma":[0.9999475,0.000007115892,0.00001551289,0.000005013799,0.000005411116,0.00001948428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003222301,0.000398242,0.0002797319,0.0001296873,0.00003641102,0.0001027626,0.00002209967,0.0000867808,0.9901668,0.0001813152,0.0001319738,0.005241996],"study_design_scores_gemma":[0.0005869595,0.00320385,0.009501258,0.00001786548,0.0001440577,0.0002406728,0.00007921883,0.001124573,0.9816445,0.0001591196,0.003285927,0.00001205166],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937801,0.002945842,0.001276947,0.0003335576,0.00009591437,0.00004041943,0.0001646765,0.0001170472,0.001245489],"genre_scores_gemma":[0.9929335,0.002361825,0.001447142,0.0001283943,0.00003779122,0.00005793662,0.0002518143,0.00002204549,0.002759588],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00105483,"threshold_uncertainty_score":0.003528714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04485624410092631,"score_gpt":0.2961193011252778,"score_spread":0.2512630570243515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}