{"id":"W2074570440","doi":"10.1371/journal.pbio.0060239","title":"A Specificity Map for the PDZ Domain Family","year":2008,"lang":"en","type":"article","venue":"PLoS Biology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":491,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Genentech","keywords":"PDZ domain; Biology; Caenorhabditis elegans; Protein domain; Mutant; Plasma protein binding; Human proteome project; Protein–protein interaction; Binding selectivity; Computational biology; Proteome; Cell biology; Genetics; Gene; Proteomics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006904476,0.0004256629,0.0002206383,0.001112287,0.000317316,0.0003558251,0.0002053246,0.0002699454,0.002110229],"category_scores_gemma":[0.0002104167,0.0001702455,0.0002125549,0.0003881097,0.0001730036,0.0002963699,0.0002858489,0.0003991419,0.001175169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003254318,"about_ca_system_score_gemma":0.0001937677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006441115,"about_ca_topic_score_gemma":0.0006191853,"domain_scores_codex":[0.9999021,0.000005665408,0.000004225475,0.00004226783,0.0000324104,0.00001330482],"domain_scores_gemma":[0.9998709,0.00002625749,0.00002883258,0.00001465168,0.00003085226,0.00002850278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001370501,0.00002872524,0.005500759,0.00007941358,0.00001527816,0.0001553334,0.00004553342,0.0008803747,0.9608588,0.001806088,0.0005696143,0.02992305],"study_design_scores_gemma":[0.00006744139,0.0004700579,0.1054204,0.00005558884,0.0001342288,0.004991949,0.0001481818,0.03401134,0.7722232,0.009747562,0.07263854,0.0000914599],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8686315,0.002165775,0.1098194,0.0001686866,0.00003374365,0.00007954272,0.005102502,0.001021653,0.01297726],"genre_scores_gemma":[0.944032,0.0007124408,0.04561656,0.0001263673,0.00001906145,0.00007076131,0.00548179,0.0001102545,0.003830808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002110229,"threshold_uncertainty_score":0.007059455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02136129055972648,"score_gpt":0.2970654815593814,"score_spread":0.2757041909996549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}