{"id":"W2074570966","doi":"10.1126/science.1136611","title":"Structural Insight into the Transglycosylation Step of Bacterial Cell-Wall Biosynthesis","year":2007,"lang":"en","type":"article","venue":"Science","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Peptidoglycan; Cell wall; Bacterial cell structure; Glycosyltransferase; Enzyme; Bacteria; Biochemistry; Biosynthesis; Phosphofructokinase 2; Chemistry; Lipid II; Bifunctional; Stereochemistry; Biology; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002308089,0.00007202612,0.00005801971,0.00002880967,0.0001176478,0.00002028801,0.0002669926,0.00006188716,0.00002446528],"category_scores_gemma":[0.00004603209,0.00004505864,0.00003440339,0.0002120751,0.0003562723,0.00001048336,0.00004264062,0.00003829664,0.00000121739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009420793,"about_ca_system_score_gemma":0.00004341386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001448568,"about_ca_topic_score_gemma":0.00002121508,"domain_scores_codex":[0.9993239,0.00001325411,0.0001510611,0.0001945756,0.0001688363,0.0001483869],"domain_scores_gemma":[0.999624,0.000009971537,0.00006831059,0.000168242,0.00008478614,0.00004469294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004973893,0.000003081182,0.0007227312,0.000005361268,0.000001479917,9.253664e-8,0.0002522317,0.000001247995,0.989862,0.00003408756,0.000003160087,0.009064788],"study_design_scores_gemma":[0.00009082037,0.00004907289,0.04652766,0.000002459738,0.000003537896,0.000001405889,0.00002758469,0.00007113784,0.9504341,0.00003902186,0.002687371,0.00006582235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986292,0.00007179546,0.0006487608,0.00008666878,0.0002131531,0.00007462684,0.000003781036,0.000004231825,0.0002677983],"genre_scores_gemma":[0.9992142,0.00001315951,0.0005111562,0.00006448453,0.000129268,7.884684e-7,0.00002799883,0.000003567648,0.0000353802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04580493,"threshold_uncertainty_score":0.1837438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006624029281540542,"score_gpt":0.2236776964175604,"score_spread":0.2170536671360199,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}