{"id":"W2074595878","doi":"10.1007/s40271-015-0123-2","title":"Patient-Reported Outcomes After a Switch to a Single-Tablet Regimen of Rilpivirine, Emtricitabine, and Tenofovir DF in HIV-1-Positive, Virologically Suppressed Individuals: Additional Findings From a Randomized, Open-Label, 48-Week Trial","year":2015,"lang":"en","type":"article","venue":"Patient","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Cilag; AbbVie Canada; Janssen Canada; Merck Canada; GlaxoSmithKline; ViiV Healthcare; Gilead Sciences; Pfizer; Bristol-Myers Squibb","keywords":"Rilpivirine; Emtricitabine; Medicine; Regimen; Tolerability; Internal medicine; Randomized controlled trial; Ritonavir; Lamivudine; Human immunodeficiency virus (HIV); Protease inhibitor (pharmacology); Pharmacology; Adverse effect; Viral load; Virology; Virus; Antiretroviral therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005032938,0.0004260679,0.001548006,0.0004405104,0.00005448635,0.00007039001,0.0001573756,0.0001613464,0.0006817798],"category_scores_gemma":[0.001710824,0.0003050554,0.0001075269,0.0004430274,0.0001252924,0.0002247027,0.0004177734,0.0001950486,0.00006266693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523899,"about_ca_system_score_gemma":0.0003368052,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001563013,"about_ca_topic_score_gemma":0.00002764482,"domain_scores_codex":[0.9964334,0.0003073547,0.001306204,0.000681911,0.0008214073,0.0004497612],"domain_scores_gemma":[0.9976342,0.000946182,0.0004137253,0.00033452,0.0002656881,0.0004056228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7219927,0.01431707,0.1965635,0.00004004243,0.001643411,0.0007345246,0.01422273,0.000007729484,0.0005152738,0.00003780434,0.04675298,0.003172184],"study_design_scores_gemma":[0.9156435,0.004197875,0.07070109,0.0005357168,0.0006499486,0.0000258572,0.0005219199,0.00009131827,0.001259755,0.0005125496,0.005240859,0.0006196797],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895155,0.0001425402,0.00006289004,0.002126688,0.0001540192,0.004998277,0.001420034,0.00003722265,0.001542838],"genre_scores_gemma":[0.9818113,0.000007983374,0.01179685,0.0008580112,0.00003421814,0.002245687,0.00189459,0.00003720021,0.0013142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1936507,"threshold_uncertainty_score":0.9999402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03556670404832139,"score_gpt":0.2744014148754535,"score_spread":0.2388347108271321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}