{"id":"W2074625189","doi":"10.1002/ijc.20383","title":"Multiple mechanisms of action of ZR2002 in human breast cancer cells: A novel combi‐molecule designed to block signaling mediated by the ERB family of oncogenes and to damage genomic DNA","year":2004,"lang":"en","type":"article","venue":"International Journal of Cancer","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Health Canada; Royal Victoria Hospital; Royal Victoria Regional Health Centre","funders":"","keywords":"Autophosphorylation; Biology; Tyrosine kinase; Signal transduction; Cell growth; Apoptosis; Cancer cell; Cell culture; Cancer research; Molecular biology; Cell biology; Kinase; Biochemistry; Cancer; Protein kinase A; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001818744,0.0001018502,0.000188078,0.0001080357,0.00001814336,0.000008795562,0.0002592716,0.00005967572,0.0000133055],"category_scores_gemma":[0.000009534461,0.00008574672,0.00006951441,0.00008316986,0.00003348116,0.000005667815,0.00005913818,0.00006274349,1.026417e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009685026,"about_ca_system_score_gemma":0.0001732031,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00115728,"about_ca_topic_score_gemma":0.0009202894,"domain_scores_codex":[0.9990872,0.00002233855,0.0004022986,0.0001237229,0.0002611495,0.0001033435],"domain_scores_gemma":[0.999068,0.00001615862,0.0003658918,0.00008513821,0.0004065112,0.00005830847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005151294,0.0001125438,0.0001091398,0.00001106355,0.0002160024,0.00000124885,0.0002115917,0.01232614,0.9853145,0.00006761283,0.00002770958,0.001087341],"study_design_scores_gemma":[0.0018904,0.0003097756,0.001123937,0.0001296977,0.00003704461,0.000009681909,0.0001607526,0.00006109807,0.9957718,0.0001243588,0.0002966805,0.00008472196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844494,0.0007410905,0.01375663,0.000367373,0.0002435882,0.0001420334,0.0002910212,9.095e-7,0.000007965541],"genre_scores_gemma":[0.9985949,0.0003012571,0.0005687454,0.0003995623,0.00008659108,0.0000119767,0.000005439043,0.00001528399,0.00001619335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01414556,"threshold_uncertainty_score":0.349665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01695906884336004,"score_gpt":0.2937833571564673,"score_spread":0.2768242883131073,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}