{"id":"W2074660718","doi":"10.1128/jvi.01468-12","title":"Herpes Simplex Virus 1 DNA Is in Unstable Nucleosomes throughout the Lytic Infection Cycle, and the Instability of the Nucleosomes Is Independent of DNA Replication","year":2012,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Li Ka Shing Institute of Virology, University of Alberta; Canadian Institutes of Health Research","keywords":"Nucleosome; Biology; DNA replication; Lytic cycle; DNA; Nucleoprotein; Eukaryotic DNA replication; Micrococcal nuclease; Histone; Control of chromosome duplication; Molecular biology; Replication factor C; Chromatin; Origin recognition complex; Viral replication; Virology; Cell biology; Virus; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001915836,0.000272672,0.0002276768,0.0002687405,0.0002496718,0.0005960041,0.0002177713,0.0002005262,0.0005989276],"category_scores_gemma":[0.000389543,0.0002045662,0.0001362729,0.0002390228,0.0002562946,0.0002803788,0.000282854,0.0004059962,0.0003204598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000507783,"about_ca_system_score_gemma":0.0003354225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001548381,"about_ca_topic_score_gemma":0.002086499,"domain_scores_codex":[0.9996523,0.00003677805,0.00003031296,0.0001101852,0.0001186708,0.00005177587],"domain_scores_gemma":[0.9998057,0.00003181152,0.00005138417,0.00002570712,0.00004427058,0.00004110863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006689618,0.000009014884,0.002268926,0.00003458254,0.000006330013,0.00002014905,0.00003841832,0.00002225701,0.995787,0.00008128987,0.00001502288,0.001650111],"study_design_scores_gemma":[0.000004708638,0.0001876008,0.04012447,0.00001727071,0.00002211065,0.0003722331,0.00008564263,0.0006616073,0.9546041,0.0001532104,0.003759122,0.000007992769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867417,0.005287213,0.00645294,0.00005476489,0.00002914639,0.00002987704,0.0003488616,0.00005929052,0.0009961944],"genre_scores_gemma":[0.992654,0.001434255,0.00284393,0.00003461408,0.00001129758,0.0000256072,0.0008988151,0.00001861697,0.002078881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548381,"threshold_uncertainty_score":0.003684282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01931567950576405,"score_gpt":0.3183019233187758,"score_spread":0.2989862438130117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}