{"id":"W2074666700","doi":"10.1074/jbc.m906994199","title":"Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":266,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"","keywords":"Inositol; Chemistry; Circular dichroism; Stereochemistry; Peptide; In vitro; Inositol phosphate; Toxicity; Amyloid (mycology); Biochemistry; Biophysics; Receptor; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002048659,0.0002009238,0.0005834327,0.00004268099,0.00004993818,0.00001525775,0.0001161372,0.0001743164,0.00102038],"category_scores_gemma":[0.00008606145,0.0001276351,0.0001999057,0.0001506256,0.0002483034,0.0001178217,0.00003893783,0.0003428985,0.000007059529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000462171,"about_ca_system_score_gemma":0.0001341558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001245449,"about_ca_topic_score_gemma":3.420161e-7,"domain_scores_codex":[0.9985143,0.00007194722,0.0005298863,0.0002265348,0.0003513769,0.0003059502],"domain_scores_gemma":[0.9986245,0.0000684265,0.0002714961,0.0002001284,0.0001622953,0.0006731258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002731691,0.001841594,0.05749762,0.000116745,0.00384674,0.000579424,0.0001010519,0.000001345465,0.916547,0.000001214669,0.00009621985,0.01663939],"study_design_scores_gemma":[0.003193688,0.002325298,0.06405495,0.0001903466,0.0005411279,0.0006852918,0.0002555454,0.00001271109,0.9282676,0.00007943867,0.0002008491,0.0001931439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931324,0.005349709,5.538735e-7,0.0001734448,0.00001523248,0.0001395693,0.0000221658,0.00001263569,0.001154336],"genre_scores_gemma":[0.9983138,0.001118411,0.0002707412,0.00008823779,0.0001473667,0.000003534632,0.0000145742,0.0000112893,0.00003203709],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01644624,"threshold_uncertainty_score":0.9998928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04693501429915862,"score_gpt":0.31403472596055,"score_spread":0.2670997116613914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}