{"id":"W2074667992","doi":"10.1016/j.chembiol.2010.04.011","title":"The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility","year":2010,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Steacie Institute for Molecular Sciences","funders":"Natural Sciences and Engineering Research Council of Canada; University of Warwick","keywords":"Small interfering RNA; RNA; Hepatitis C virus; Biology; Virology; Computational biology; Genome; Viral replication; RNA interference; Trans-acting siRNA; Virus; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006506878,0.0003384594,0.0004721736,0.0003781527,0.0002644443,0.0007245581,0.0002150706,0.000368118,0.001631321],"category_scores_gemma":[0.000955599,0.0004260383,0.0003236762,0.0001499925,0.0005051902,0.0004124231,0.0003804602,0.0004525227,0.0006776316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003241292,"about_ca_system_score_gemma":0.0002061383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002788257,"about_ca_topic_score_gemma":0.0004862225,"domain_scores_codex":[0.9995413,0.000135289,0.00004076704,0.0000936069,0.000116916,0.00007219466],"domain_scores_gemma":[0.999083,0.0004679163,0.000184051,0.00009080882,0.00008416595,0.00009004011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008411278,0.000006209909,0.0002016314,0.00001616098,0.000004855006,0.0000124454,0.000006569764,0.00007108369,0.998628,0.00008308521,0.00001509609,0.0008706238],"study_design_scores_gemma":[0.000009960702,0.0001593466,0.00581557,0.00000308471,0.00001277435,0.0001051604,0.000009820791,0.0009109501,0.99234,0.0001129791,0.0005123613,0.000008097646],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884448,0.002809566,0.004692838,0.0001031348,0.00003259165,0.00002184289,0.0001415277,0.0001240696,0.003629562],"genre_scores_gemma":[0.9977478,0.0004481892,0.0008074034,0.00003563691,0.000009136052,0.00001559857,0.0001382763,0.00003062602,0.0007672434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631321,"threshold_uncertainty_score":0.005457282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003973106672132266,"score_gpt":0.2465218162017385,"score_spread":0.2425487095296062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}