{"id":"W2074667992","doi":"10.1016/j.chembiol.2010.04.011","title":"The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility","year":2010,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Steacie Institute for Molecular Sciences","funders":"Natural Sciences and Engineering Research Council of Canada; University of Warwick","keywords":"Small interfering RNA; RNA; Hepatitis C virus; Biology; Virology; Computational biology; Genome; Viral replication; RNA interference; Trans-acting siRNA; Virus; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009762483,0.0001898477,0.0001866278,0.000007708045,0.0001136439,0.00002552461,0.0003678201,0.000373385,0.00008784789],"category_scores_gemma":[0.0001854561,0.0001392884,0.00006921162,0.00004780533,0.0005291991,0.000005192574,0.000197036,0.0002392953,0.000002201282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005719091,"about_ca_system_score_gemma":0.00006481694,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008983733,"about_ca_topic_score_gemma":0.00008051415,"domain_scores_codex":[0.9989496,0.00002914478,0.0002718939,0.0004332362,0.00005923255,0.0002568311],"domain_scores_gemma":[0.9990669,0.00003958431,0.0001614614,0.0005275916,0.0001226241,0.00008180786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007429493,0.00002235309,0.07674197,0.00001458123,0.0000421829,4.331768e-7,0.00002788874,0.000001362086,0.9195352,0.000002444758,0.001243361,0.002293994],"study_design_scores_gemma":[0.0003333818,0.00008176952,0.01766562,0.000004316,0.000009727018,0.000005055648,0.00001325719,0.00002006766,0.968209,0.00009251156,0.01341407,0.0001512195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979029,0.0009826999,0.00001871675,0.00009206642,0.0001320159,0.00009135204,0.0005210012,0.000007892614,0.0002514109],"genre_scores_gemma":[0.9982285,0.0006453496,0.0001014196,0.0001917542,0.0001557958,0.000006991261,0.0004513656,0.00001087328,0.0002079683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05907635,"threshold_uncertainty_score":0.5680018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003973106672132266,"score_gpt":0.2465218162017385,"score_spread":0.2425487095296062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}