{"id":"W2074679890","doi":"10.1073/pnas.1203633109","title":"Sources of energy for gating by neurotransmitters in acetylcholine receptor channels","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research","keywords":"Gating; Acetylcholine receptor; Agonist; Biophysics; Acetylcholine; Chemistry; Stereochemistry; Nicotinic acetylcholine receptor; Receptor; Binding site; Biochemistry; Biology; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003133089,0.0005534875,0.0004101698,0.0006073884,0.000374546,0.0004558051,0.0003185515,0.0003362435,0.0008208898],"category_scores_gemma":[0.0007123061,0.0002101344,0.0004263979,0.0004345594,0.0004365258,0.000486528,0.0003504845,0.0005134593,0.0001225126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004582705,"about_ca_system_score_gemma":0.0002142729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006838985,"about_ca_topic_score_gemma":0.0008510607,"domain_scores_codex":[0.9998195,0.00002297583,0.00001382098,0.00004753004,0.00005240609,0.00004382867],"domain_scores_gemma":[0.9998049,0.00008927532,0.00003332563,0.00001967357,0.00002511892,0.00002761562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004871796,0.0000944075,0.01124572,0.00009853671,0.00008050458,0.0002578442,0.00009274605,0.01125841,0.9672213,0.001924678,0.00006032937,0.007178317],"study_design_scores_gemma":[0.00008117981,0.000493621,0.07913693,0.00004395288,0.0002036229,0.001142753,0.0001848084,0.100329,0.8126627,0.004552073,0.001094126,0.00007510483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966324,0.0002640985,0.002767563,0.00002001426,0.000004766584,0.000004562769,0.00004179215,0.00001097369,0.0002539345],"genre_scores_gemma":[0.9984826,0.0001272307,0.001077208,0.00001081677,0.000001264276,0.00000910235,0.0001095506,0.00001228601,0.0001699429],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008208898,"threshold_uncertainty_score":0.003324986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02686809157441207,"score_gpt":0.2997867663209019,"score_spread":0.2729186747464898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}