{"id":"W2074687765","doi":"10.1073/pnas.250494697","title":"Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras","year":2000,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cancer Institute; Foundation for Promotion of Cancer Research; Memorial Sloan-Kettering Cancer Center","keywords":"HDAC4; MAPK/ERK pathway; Kinase; Cell biology; Biology; Signal transduction; Chromatin remodeling; Histone deacetylase; Protein kinase A; Histone deacetylase 5; c-Raf; Molecular biology; Histone; Chemistry; Biochemistry; Mitogen-activated protein kinase kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006719301,0.0001341694,0.0001560938,0.00008307291,0.0002487195,0.00002581122,0.0002627124,0.0001670226,0.00004438859],"category_scores_gemma":[0.0001284382,0.00009903254,0.0000387766,0.0004496181,0.0008581979,0.00003796129,0.00007270554,0.0001085899,9.441191e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003258094,"about_ca_system_score_gemma":0.00004777927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001354138,"about_ca_topic_score_gemma":1.902671e-7,"domain_scores_codex":[0.9983877,0.00001896013,0.0002620019,0.0003731028,0.0007716162,0.000186638],"domain_scores_gemma":[0.9993557,0.00002796647,0.0002290097,0.00001354572,0.0003059279,0.00006782389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000630771,0.00004968463,0.0003692282,0.00003982089,0.00002840057,3.54236e-8,0.00008227018,0.00007901837,0.9965292,0.0001282639,0.002292347,0.0003386327],"study_design_scores_gemma":[0.0003853292,0.0001640135,0.000650466,0.00006225997,0.00002074618,0.00001611455,0.00003764261,0.002460693,0.9943346,0.0002801357,0.001464854,0.0001231065],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936493,0.005060458,0.000002536537,0.0007454926,0.000003141166,0.0002102286,0.00003317101,0.000006833316,0.0002888204],"genre_scores_gemma":[0.9971778,0.0003133915,0.0001120614,0.00009760072,0.00003055231,0.000007636145,0.000004463679,0.00001015728,0.002246355],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004747066,"threshold_uncertainty_score":0.403843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01420476567864568,"score_gpt":0.273426382559069,"score_spread":0.2592216168804233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}