{"id":"W2074728653","doi":"10.1523/jneurosci.3292-05.2006","title":"Calcium Calmodulin-Stimulated Adenylyl Cyclases Contribute to Activation of Extracellular Signal-Regulated Kinase in Spinal Dorsal Horn Neurons in Adult Rats and Mice","year":2006,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; U.S. Public Health Service; National Institutes of Health","keywords":"Spinal cord; Adenylyl cyclase; MAPK/ERK pathway; Extracellular; Glutamate receptor; Nociception; Neuroscience; Calcium; Nociceptor; Cell biology; Biology; Signal transduction; Internal medicine; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002991619,0.0001514466,0.0003633256,0.0004302602,0.00004252184,0.000020847,0.0001029315,0.00006648277,0.000003254633],"category_scores_gemma":[0.0003639531,0.0001255208,0.00005443494,0.0006892021,0.00008050851,0.0002081418,0.00002847877,0.0002451561,6.096166e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008851616,"about_ca_system_score_gemma":0.0001119683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002487166,"about_ca_topic_score_gemma":0.00002155085,"domain_scores_codex":[0.9983766,0.0001049759,0.0005935653,0.000244359,0.0004131946,0.0002672909],"domain_scores_gemma":[0.9991575,0.00008132854,0.0002974172,0.0001100551,0.0002078566,0.0001457808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008081175,0.0005342687,0.01052804,0.00001962447,0.000002846478,0.001277407,0.00003408921,0.003693573,0.982476,0.0000323287,0.0000141604,0.0005795631],"study_design_scores_gemma":[0.002820988,0.001719944,0.5802588,0.000383599,0.00003294793,0.0002855961,0.0000189036,0.01377584,0.4005008,0.0000715394,0.00003624112,0.00009483974],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964327,0.0001303451,0.002172041,0.0008436879,0.0001192818,0.0002819639,0.000007809653,0.000005552625,0.000006570389],"genre_scores_gemma":[0.9992824,0.00001602075,0.0003664657,0.0002341959,0.00003325051,0.00000213518,0.000001710481,0.00001062497,0.00005326426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5819752,"threshold_uncertainty_score":0.5118588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053551077864649,"score_gpt":0.28405892886411,"score_spread":0.2635234180854635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}